Journal article
Colorimetric and visual dopamine assay based on the use of gold nanorods
Microchimica Acta, Vol.184(10), pp.4125-4132
2017
Abstract
The authors describe an optical method for the determination of dopamine (DA). It is based on the use of gold nanorods (AuNRs) with an aspect ratio of 3.2 and an absorption maximum at 700 nm. The AuNRs were synthesized via a seed-mediated growth route. The addition of various DA concentrations to the aqueous AuNRs results in a color change bluish-purple to colorless. The addition of DA is accompanied by a linear decrease in absorbance, a blue-shift of the peak to 687 nm, and the formation of a new band peaking at 720 nm on increasing in the DA concentration to 100 μM. It is found that DA causes an aggregation of the AuNRs through the formation of interparticle plasmon-linkages between DA molecules and AuNRs. This was confirmed by transmission electron microscopy. This new colorimetric probe for DA shows good selectivity for DA even in the presence of potentially interfering species. Several linearranges are observed between the changes in absorption at around 687 and at around 720 nm and the DA concentration in the range between 100 nM and 10 mM. The limit of detection is 30 nM. The method was successfully employed to the determination of DA in spiked human urine samples.
Details
- Title
- Colorimetric and visual dopamine assay based on the use of gold nanorods
- Authors/Creators
- P.S. Teo (Author/Creator)P. Rameshkumar (Author/Creator)A. Pandikumar (Author/Creator)Z-T Jiang (Author/Creator)M. Altarawneh (Author/Creator)N.M. Huang (Author/Creator)
- Publication Details
- Microchimica Acta, Vol.184(10), pp.4125-4132
- Publisher
- Springer Vienna
- Identifiers
- 991005542392707891
- Copyright
- © Springer-Verlag GmbH Austria 2017
- Murdoch Affiliation
- School of Engineering and Information Technology
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 2 Chemistry
- 2.145 Biosensors
- 2.145.243 Nanobiosensors
- Web Of Science research areas
- Chemistry, Analytical
- ESI research areas
- Chemistry