Journal article
Combined analysis of Genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci
The American Journal of Human Genetics, Vol.90(4), pp.636-647
2012
Abstract
Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically, pathologically, and therapeutically connected, but little is known about their shared genetic causes. We performed meta-analyses of five published genome-wide association studies on PS (2,529 cases and 4,955 controls) and CD (2,142 cases and 5,505 controls), followed up 20 loci that showed strongest evidence for shared disease association and, furthermore, tested cross-disease associations for previously reported PS and CD risk alleles in additional 6,115 PS cases, 4,073 CD cases, and 10,100 controls. We identified seven susceptibility loci outside the human leukocyte antigen region (9p24 near JAK2, 10q22 at ZMIZ1, 11q13 near PRDX5, 16p13 near SOCS1, 17q21 at STAT3, 19p13 near FUT2, and 22q11 at YDJC) shared between PS and CD with genome-wide significance (p < 5 × 10−8) and confirmed four already established PS and CD risk loci (IL23R, IL12B, REL, and TYK2). Three of the shared loci are also genome-wide significantly associated with PS alone (10q22 at ZMIZ1, prs1250544 = 3.53 × 10−8, 11q13 near PRDX5, prs694739 = 3.71 × 10−09, 22q11 at YDJC, prs181359 = 8.02 × 10−10). In addition, we identified one susceptibility locus for CD (16p13 near SOCS1, prs4780355 = 4.99 × 10−8). Refinement of association signals identified shared genome-wide significant associations for exonic SNPs at 10q22 (ZMIZ1) and in silico expression quantitative trait locus analyses revealed that the associations at ZMIZ1 and near SOCS1 have a potential functional effect on gene expression. Our results show the usefulness of joint analyses of clinically distinct immune-mediated diseases and enlarge the map of shared genetic risk loci.
Details
- Title
- Combined analysis of Genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci
- Authors/Creators
- D. Ellinghaus (Author/Creator) - Christian-Albrechts-Universität zu KielE. Ellinghaus (Author/Creator) - Christian-Albrechts-Universität zu KielR.P. Nair (Author/Creator) - University of MichiganP.E. Stuart (Author/Creator) - University of MichiganT. Esko (Author/Creator) - University of TartuA. Metspalu (Author/Creator) - University of TartuS. Debrus (Author/Creator) - Global Affairs CanadaJ.V. Raelson (Author/Creator) - PGX-Services, Montreal, QC H2T 1S1, CanadaT. Tejasvi (Author/Creator) - University of MichiganM. Belouchi (Author/Creator) - Genizon BioSciences, Inc., St. Laurent, QC H4T 2C7, CanadaS.L. West (Author/Creator) - King's College LondonJ.N. Barker (Author/Creator) - King's College LondonS. Kõks (Author/Creator) - University of TartuK. Kingo (Author/Creator) - University of TartuT. Balschun (Author/Creator) - Christian-Albrechts-Universität zu KielO. Palmieri (Author/Creator) - Casa Sollievo della SofferenzaV. Annese (Author/Creator) - Casa Sollievo della SofferenzaC. Gieger (Author/Creator) - Helmholtz Zentrum MünchenH.E. Wichmann (Author/Creator) - Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, 81377 Munich, GermanyM. Kabesch (Author/Creator) - Medizinische Hochschule HannoverR.C. Trembath (Author/Creator) - King's College LondonC.G. Mathew (Author/Creator) - King's College LondonG.R. Abecasis (Author/Creator) - University of MichiganS. Weidinger (Author/Creator) - University Hospital Schleswig-HolsteinS. Nikolaus (Author/Creator) - Christian-Albrechts-Universität zu KielS. Schreiber (Author/Creator) - Christian-Albrechts-Universität zu KielJ.T. Elder (Author/Creator) - University of MichiganM. Weichenthal (Author/Creator) - University Hospital Schleswig-HolsteinM. Nothnagel (Author/Creator) - Christian-Albrechts-Universität zu KielA. Franke (Author/Creator) - Christian-Albrechts-Universität zu Kiel
- Publication Details
- The American Journal of Human Genetics, Vol.90(4), pp.636-647
- Publisher
- Cell Press
- Identifiers
- 991005540875207891
- Copyright
- © 2012 The American Society of Human Genetics.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.737 Psoriasis
- Web Of Science research areas
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics