Journal article
Combined haplotype analysis of the interleukin-19 and -20 genes: Relationship to plaque-type psoriasis
Genes & Immunity, Vol.5(8), pp.662-667
2004
Abstract
There is increasing evidence to suggest that the newly discovered cytokines interleukin (IL)-19 and -20 have a role in the function of epidermis and in psoriasis. The genes encoding these cytokines locate into the genomic IL-10 region on human chromosome 1. The aim of the present study was to analyze whether single-nucleotide polymorphisms (SNPs) in these genes have an impact on the susceptibility for psoriasis. From pairwise linkage disequilibrium (LD) matrix of the IL-19 and -20 gene polymorphisms, what reflects the nonrandom association of alleles at these markers, it was apparent that IL-19 and -20 genes form one block of LD. We found that the HT3 CACCGGAA haplotype of the IL-19 and -20 genes was associated with an increased risk of psoriasis, reflecting its role in determining susceptibility to plaque-type psoriasis. Although association analysis of the IL-19 gene indicated that minor alleles of the IL-19 gene SNPs (rs2243188, rs2243169 and rs2243158) revealed protective effect to psoriasis and haplotype analysis of the IL-19 gene proved significant protective effect of the TGATA haplotype in case of late-onset disease, combined haplotype analysis of the IL-19 and -20 genes demonstrated that protective effect of the IL-19 gene is secondary to the susceptibility effect of the IL-20 gene.
Details
- Title
- Combined haplotype analysis of the interleukin-19 and -20 genes: Relationship to plaque-type psoriasis
- Authors/Creators
- S. Kõks (Author/Creator)K. Kingo (Author/Creator)R. Rätsep (Author/Creator)M. Karelson (Author/Creator)H. Silm (Author/Creator)E. Vasar (Author/Creator)
- Publication Details
- Genes & Immunity, Vol.5(8), pp.662-667
- Publisher
- Springer Nature
- Identifiers
- 991005542130807891
- Copyright
- © 2019 Springer Nature Limited
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.487 Regulatory T Cells
- Web Of Science research areas
- Genetics & Heredity
- Immunology
- ESI research areas
- Molecular Biology & Genetics