Journal article
Common data elements to standardize genomics studies in cerebral palsy
Developmental Medicine & Child Neurology, Vol.64(12), pp.1470-1476
2022
Abstract
Aim
To define clinical common data elements (CDEs) and a mandatory minimum data set (MDS) for genomic studies of cerebral palsy (CP).
Method
Candidate data elements were collated following a review of the literature and existing CDEs. An online, three-round Delphi survey was used to rate each data element as either ‘core’, ‘recommended’, ‘exploratory’, or ‘not required’. Members of the International Cerebral Palsy Genomics Consortium (ICPGC) rated the core CDEs as either mandatory or not, to form the MDS. For both the CDEs and the MDS, a data element was considered to have reached consensus if more than 75% of respondents agreed.
Results
Forty-six individuals from around the world formed the Delphi panel: consumers (n=2), scientists/researchers (n=17), medical (n=19), and allied health professionals (n=8). The CDEs include 107 data elements across six categories: demographics, diagnostics, family history, antenatal and neonatal details, clinical traits, and CP-specific assessments. Of these, 10 are mandatory, 42 core, 41 recommended, and 14 are exploratory.
Interpretation
The ICPGC CDEs provide a foundation for the standardization of phenotype data captured in CP genomic studies and will benefit international collaborations and pooling of data, particularly in rare conditions.
Details
- Title
- Common data elements to standardize genomics studies in cerebral palsy
- Authors/Creators
- Y.A. Wilson (Author/Creator) - Cerebral Palsy AllianceH. Smithers‐Sheedy (Author/Creator)K. Ostojic (Author/Creator) - Cerebral Palsy AllianceE. Waight (Author/Creator) - Cerebral Palsy AllianceM.C. Kruer (Author/Creator) - Barrow Neurological InstituteM.C. Fahey (Author/Creator) - Monash UniversityG. Baynam (Author/Creator) - King Edward Memorial HospitalJ. Gecz (Author/Creator) - The University of AdelaideN. Badawi (Author/Creator) - Cerebral Palsy AllianceS. McIntyre (Author/Creator) - Cerebral Palsy Alliance
- Publication Details
- Developmental Medicine & Child Neurology, Vol.64(12), pp.1470-1476
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005540575307891
- Copyright
- John Wiley & Sons Ltd on behalf of Mac Keith Press.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.1066 Cerebral Palsy
- Web Of Science research areas
- Clinical Neurology
- Pediatrics
- ESI research areas
- Neuroscience & Behavior