Common genetic variation and the control of HIV-1 in humans

J. Fellay; D. Ge; K.V. Shianna; S. Colombo; B. Ledergerber; E.T. Cirulli; T.J. Urban; K. Zhang; C.E. Gumbs; J. P. Smith; A. Castagna; A. Cozzi-Lepri; A. De Luca; P. Easterbrook; H.F. Günthard; S. Mallal; C. Mussini; J. Dalmau; J. Martinez-Picado; J.M. Miro; N. Obel; S.M. Wolinsky; J.J. Martinson; R. Detels; J.B. Margolick; L.P. Jacobson; P. Descombes; S.E. Antonarakis; J.S. Beckmann; S.J. O'Brien; N.L. Letvin; A.J. McMichael; B.F. Haynes; M. Carrington; S. Feng; A. Telenti; D.B. Goldstein; M.I. McCarthy

doi:10.1371/journal.pgen.1000791

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Common genetic variation and the control of HIV-1 in humans

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Common genetic variation and the control of HIV-1 in humans

J. Fellay, D. Ge, K.V. Shianna, S. Colombo, B. Ledergerber, E.T. Cirulli, T.J. Urban, K. Zhang, C.E. Gumbs, J. P. Smith, …

PLoS Genetics, Vol.5(12), e1000791

2009

DOI: https://doi.org/10.1371/journal.pgen.1000791

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Abstract

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.

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Title: Common genetic variation and the control of HIV-1 in humans
Authors/Creators: J. Fellay (Author/Creator) - Duke University
D. Ge (Author/Creator) - Duke University
K.V. Shianna (Author/Creator) - Duke University
S. Colombo (Author/Creator) - University of Lausanne
B. Ledergerber (Author/Creator) - University of Zurich
E.T. Cirulli (Author/Creator) - Duke University
T.J. Urban (Author/Creator) - Duke University
K. Zhang (Author/Creator) - University of Lausanne
C.E. Gumbs (Author/Creator) - Duke University
J. P. Smith (Author/Creator) - Duke University
A. Castagna (Author/Creator) - Vita-Salute San Raffaele University
A. Cozzi-Lepri (Author/Creator) - University College London
A. De Luca (Author/Creator) - University of the Sacred Heart
P. Easterbrook (Author/Creator) - Guy's and St Thomas' NHS Foundation Trust
H.F. Günthard (Author/Creator) - University of Zurich
S. Mallal (Author/Creator) - Murdoch University
C. Mussini (Author/Creator) - Infectious Diseases Clinic
J. Dalmau (Author/Creator) - Universitat Autònoma de Barcelona
J. Martinez-Picado (Author/Creator) - Autonomous University of Barcelona
J.M. Miro (Author/Creator) - Universitat de Barcelona
N. Obel (Author/Creator) - University of Copenhagen
S.M. Wolinsky (Author/Creator) - Northwestern University
J.J. Martinson (Author/Creator) - University of Pittsburgh
R. Detels (Author/Creator) - University of California at Los Angeles
J.B. Margolick (Author/Creator) - Johns Hopkins University
L.P. Jacobson (Author/Creator) - Johns Hopkins University
P. Descombes (Author/Creator) - University of Geneva
S.E. Antonarakis (Author/Creator) - University of Geneva
J.S. Beckmann (Author/Creator) - University of Lausanne
S.J. O'Brien (Author/Creator) - National Institutes of Health
N.L. Letvin (Author/Creator) - Harvard University
A.J. McMichael (Author/Creator) - Oxford University Hospitals NHS Trust
B.F. Haynes (Author/Creator) - Duke University
M. Carrington (Author/Creator) - Massachusetts Institute of Technology
S. Feng (Author/Creator) - Duke University
A. Telenti (Author/Creator) - University of Lausanne
D.B. Goldstein (Author/Creator) - Duke University
M.I. McCarthy (Author/Creator)
Publication Details: PLoS Genetics, Vol.5(12), e1000791
Publisher: Public Library of Science
Identifiers: 991005545138407891
Copyright: Creative Commons Attribution License
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics; Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV Pathogenesis
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics