Journal article
Community-associated versus healthcare-associated methicillin-resistant Staphylococcus aureus bacteraemia: a 10-year retrospective review
European Journal of Clinical Microbiology & Infectious Diseases, Vol.28(4), pp.353-361
2009
Abstract
The objective was to compare the epidemiology and outcome of healthcare- (HA-) and community-associated (CA-) MRSA bacteraemia. A 10-year retrospective study of MRSA bacteraemia was carried out. Episodes were classified according to established criteria. Molecular typing was performed on a subset of isolates. Of 197 MRSA bacteraemia episodes, 178 (90.4%) were classified as HA-MRSA and 19 (9.6%) as CA-MRSA. All-cause 7- and 30-day mortality rates were similar in the HA and CA-MRSA bacteraemia groups; however, 1-year mortality was higher in the HA-MRSA bacteraemia group (48.3% vs 21.1% [p∈=∈0.023]). Thirty-day all-cause mortality was significantly lower if empiric antimicrobial therapy included agent(s) to which the isolate tested susceptible, compared with patients receiving "inactive" therapy (19% vs 35.1% [p∈=∈0.011]). The majority of MRSA bacteraemia episodes were caused by clones known to circulate in the community. All-cause mortality is as high in HA- as in CA-MRSA bacteraemia. Thirty-day mortality was significantly reduced if the patient received an antibiotic with activity against the MRSA isolate.
Details
- Title
- Community-associated versus healthcare-associated methicillin-resistant Staphylococcus aureus bacteraemia: a 10-year retrospective review
- Authors/Creators
- J.O. Robinson (Author/Creator) - Royal Perth HospitalJ.C. Pearson (Author/Creator) - Royal Perth HospitalK.J. Christiansen (Author/Creator) - Curtin UniversityG.W. Coombs (Author/Creator) - Curtin UniversityR.J. Murray (Author/Creator) - Royal Perth Hospital
- Publication Details
- European Journal of Clinical Microbiology & Infectious Diseases, Vol.28(4), pp.353-361
- Publisher
- Springer Verlag
- Identifiers
- 991005545383307891
- Copyright
- © 2008 Springer-Verlag.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
- Additional Information
- Young Investigators Day 2007 award
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.173 MRSA and VRE
- Web Of Science research areas
- Infectious Diseases
- Microbiology
- ESI research areas
- Microbiology