Journal article
Community-onset Staphylococcus aureus infections presenting to general practices in South-eastern Australia
Epidemiology and Infection, Vol.142(03), pp.501-511
2014
Abstract
Community-acquired Staphylococcus aureus infections are a public health concern, yet little is known about infections that do not present to hospital. We identified community-onset S. aureus infections via specimens submitted to a community-based pathology service. Referring doctors confirmed eligibility and described infection site, severity and treatment. Isolates were characterized on antibiotic resistance, PFGE, MLST/SCCmec, and Panton-Valentine leukocidin (PVL), representing 106 community-onset infections; 34 non-multiresistant methicillin-resistant S. aureus (nmMRSA) (resistant to <3 non-β-lactam antibiotics), 15 multiply antibiotic-resistant MRSA (mMRSA) and 57 methicillin-sensitive S. aureus (MSSA). Most (93%) were skin and soft tissue infections. PVL genes were carried by 42% of nmMRSA isolates [95% confidence interval (CI) 26-61] and 15% of MSSA (95% CI 8-28). PVL was associated with infections of the trunk, head or neck (56·4% vs. 24·3%, P=0·005) in younger patients (23 vs. 52 years, P<0·001), and with boils or abscesses (OR 8·67, 95% CI 2·9-26·2), suggesting underlying differences in exposure and/or pathogenesis.
Details
- Title
- Community-onset Staphylococcus aureus infections presenting to general practices in South-eastern Australia
- Authors/Creators
- C.M. Bennett (Author/Creator)G.W. Coombs (Author/Creator)G.M. Wood (Author/Creator)B.P. Howden (Author/Creator)L.E.A. Johnson (Author/Creator)D. White (Author/Creator)P.D.R. Johnson (Author/Creator)
- Publication Details
- Epidemiology and Infection, Vol.142(03), pp.501-511
- Publisher
- Cambridge University Press
- Identifiers
- 991005543456507891
- Copyright
- © 2013 Cambridge University Press.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.173 MRSA and VRE
- Web Of Science research areas
- Infectious Diseases
- Public, Environmental & Occupational Health
- ESI research areas
- Social Sciences, general