Journal article
Comparable conditioned pain modulation and painful-exercise-induced hypoalgesia in healthy young adults: A randomised crossover trial
The Journal of Pain, Vol.25(12), 104670
2024
Abstract
Conditioned pain modulation and exercise-induced hypoalgesia reflect inhibitory pain controls emanating from the brain. The aim of this study was to compare the extent of pain inhibition from exercise-induced hypoalgesia (isometric wall squat), conditioned pain modulation (cold-water immersion), and their combination (wall squat followed by cold water in fixed order) in healthy pain-free adults. Sixty-one participants (median age 21 years) completed three sessions (Wall-squat, Cold-water, Combined) in random order. Sessions were separated by at least a week. In each session, pressure-pain thresholds, single-pinprick-pain ratings, and pinprick-temporal summation of pain (the fifth minus the first) were obtained at quadriceps, forearms, and forehead, before and after wall squat and/or cold water. Each intervention inhibited pain to pressure (partial η2 =.26) and single pinprick (partial η2 =.16) to a similar extent; however, pressure-pain inhibition was negligible in the forehead. After adjusting for age and sex, single-pinprick-pain inhibition in the forehead induced by wall squat was associated with that induced by cold water (adjusted R2 =.15; p =.007), and stronger pain inhibition was predicted by a higher thigh-pain rating to wall squat (adjusted R2 =.10; p =.027). Neither intervention affected pinprick-temporal summation of pain. Together, the findings suggest that pain inhibitory effects of exercise-induced hypoalgesia and conditioned pain modulation may overlap when exercise is at least moderately painful (6/10 intensity). Pressure-pain in body regions remote from the exercised or conditioned sites may be weakly modulated.
Details
- Title
- Comparable conditioned pain modulation and painful-exercise-induced hypoalgesia in healthy young adults: A randomised crossover trial
- Authors/Creators
- Di YePeter Drummond - Murdoch University, Centre for Healthy AgeingDr Lechi Vo - Murdoch University, Centre for Healthy Ageing
- Publication Details
- The Journal of Pain, Vol.25(12), 104670
- Publisher
- Elsevier Inc. on behalf of United States Association for the Study of Pain, Inc All rights are reserved, including those for text and data mining, AI training, and similar technologies.
- Identifiers
- 991005699966707891
- Copyright
- © 2024 Published by Elsevier.
- Murdoch Affiliation
- School of Psychology; Centre for Healthy Ageing
- Resource Type
- Journal article
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