Comparative Epidemiology of Rabbit Haemorrhagic Disease Virus Strains from Viral Sequence Data

Carlo Pacioni; Robyn N. Hall; Tanja Strive; David S. L. Ramsey; Mandev S. Gill; Timothy G. Vaughan

doi:10.3390/v15010021

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Comparative Epidemiology of Rabbit Haemorrhagic Disease Virus Strains from Viral Sequence Data

Journal article

Open access

Peer reviewed

Comparative Epidemiology of Rabbit Haemorrhagic Disease Virus Strains from Viral Sequence Data

Carlo Pacioni, Robyn N. Hall, Tanja Strive, David S. L. Ramsey, Mandev S. Gill and Timothy G. Vaughan

Viruses, Vol.15(1), 21

2022

DOI: https://doi.org/10.3390/v15010021

PMCID: PMC9865945

PMID: 36680062

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Abstract

RNA virus

Birth Death models

Infectious Diseases

calicivirus

phylodynamics

RHDV

Virology

coalescent

calicivirus; RHDV; phylodynamics; RNA virus; coalescent; Birth Death models

Since their introduction in 1859, European rabbits (Oryctolagus cuniculus) have had a devastating impact on agricultural production and biodiversity in Australia, with competition and land degradation by rabbits being one of the key threats to agricultural and biodiversity values in Australia. Biocontrol agents, with the most important being the rabbit haemorrhagic disease virus 1 (RHDV1), constitute the most important landscape-scale control strategies for rabbits in Australia. Monitoring field strain dynamics is complex and labour-intensive. Here, using phylodynamic models to analyse the available RHDV molecular data, we aimed to: investigate the epidemiology of various strains, use molecular data to date the emergence of new variants and evaluate whether different strains are outcompeting one another. We determined that the two main pathogenic lagoviruses variants in Australia (RHDV1 and RHDV2) have had similar dynamics since their release, although over different timeframes (substantially shorter for RHDV2). We also found a strong geographic difference in their activities and evidence of overall competition between the two viruses.

Details

Title: Comparative Epidemiology of Rabbit Haemorrhagic Disease Virus Strains from Viral Sequence Data
Authors/Creators: Carlo Pacioni
Robyn N. Hall
Tanja Strive
David S. L. Ramsey
Mandev S. Gill
Timothy G. Vaughan
Publication Details: Viruses, Vol.15(1), 21
Publisher: MDPI
Identifiers: 991005622469807891
Murdoch Affiliation: Centre for Terrestrial Ecosystem Science and Sustainability
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.246 Diarrheal Diseases; 1.246.710 Enteric Viruses
Web Of Science research areas: Virology
ESI research areas: Microbiology