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CC BY-NC-ND V4.0, Open Access
Journal article
Comparative genomics of the highly halophilic Haloferacaceae
Scientific reports, Vol.14(1), 27025
2024
PMID: 39506039
Abstract
The Haloferacaceae are a family of extremely halophilic archaea with many species producing enzymes and products beneficial for industrial biotechnology. They are, however, relatively under-characterised with regards to genetics and gene products. This study aims to use existing sequence data to highlight genetic diversity, create pangenomes for three genera, and provide secondary metabolite and pathway analysis. This will establish current knowledge and identify key gaps in research. We show that the Haloferacaceae have significant genetic diversity between genera, with numerous gene gain and loss events in key genera. It also found that the model genus, Haloferax, has relatively low identified secondary metabolites compared to other genera within the family. Additionally, this study has identified potential biotechnology targets for heterologous expression in model organisms.
Details
- Title
- Comparative genomics of the highly halophilic Haloferacaceae
- Authors/Creators
- Dana B. Griffiths - Perth, WA 6150 Australia Perth, WA 6150 AustraliaRavi P. Tiwari - Murdoch UniversityDaniel V. Murphy - Murdoch UniversityColin Scott - Murdoch University
- Publication Details
- Scientific reports, Vol.14(1), 27025
- Publisher
- Nature Publishing Group UK
- Identifiers
- 991005714963207891
- Copyright
- © The Author(s) 2024
- Murdoch Affiliation
- Centre for Sustainable Farming Systems; School of Medical, Molecular and Forensic Sciences
- Language
- English
- Resource Type
- Journal article
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