Comparative studies of the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureusvaccine against bovine mastitis using non-invasive mouse mastitis as a model system

J. Gogoi-Tiwari; V. Williams; C.B. Waryah; K.Y. Eto; M. Tau; P. Costantino; H.K. Tiwari; T. Mukkur

doi:10.1080/08927014.2015.1074681

Back

Comparative studies of the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureusvaccine against bovine mastitis using non-invasive mouse mastitis as a model system

Journal article

Peer reviewed

Comparative studies of the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureusvaccine against bovine mastitis using non-invasive mouse mastitis as a model system

J. Gogoi-Tiwari, V. Williams, C.B. Waryah, K.Y. Eto, M. Tau, P. Costantino, H.K. Tiwari and T. Mukkur

Biofouling, Vol.31(7), pp.543-554

2015

DOI: https://doi.org/10.1080/08927014.2015.1074681

Files and links (1)

url

Link to Published Version *Subscription may be requiredView

Abstract

This study was undertaken to compare the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine for the prevention of mastitis using the mouse as a model system. Mice immunized with formalin-killed whole cell vaccine of S. aureus residing in a biofilm when delivered via an intramammary route produced a cell mediated immune response. Mice immunized with this biofilm vaccine showed significant reductions in colonization by S. aureus in mammary glands, severity of clinical symptoms and tissue damage in mammary glands in comparison with the mice immunized with formalin-killed whole cells of planktonic S. aureus. The planktonic vaccine administered by a subcutaneous route produced a significantly higher humoral immune response (IgG1 and IgG) than the biofilm vaccine. However, considering the host response, tissue damage, the clinical severity and colonization of S. aureus in mammary glands, the biofilm vaccine performed better in immunogenicity and protective potential when administered by the intramammary route.

Details

Title: Comparative studies of the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureusvaccine against bovine mastitis using non-invasive mouse mastitis as a model system
Authors/Creators: J. Gogoi-Tiwari (Author/Creator) - Curtin University
V. Williams (Author/Creator) - Curtin University
C.B. Waryah (Author/Creator) - Curtin University
K.Y. Eto (Author/Creator) - Curtin University
M. Tau (Author/Creator) - Curtin University
P. Costantino (Author/Creator) - Curtin University
H.K. Tiwari (Author/Creator) - Murdoch University
T. Mukkur (Author/Creator) - Curtin University
Publication Details: Biofouling, Vol.31(7), pp.543-554
Publisher: Taylor & Francis
Identifiers: 991005544710107891
Copyright: © 2015 Taylor & Francis
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

29 Record Views

21 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.42 Bacteriology; 1.42.567 Quorum Sensing
Web Of Science research areas: Biotechnology & Applied Microbiology; Marine & Freshwater Biology
ESI research areas: Plant & Animal Science