Comparative study of the antioxidant defence systems in the erythrocytes of australian marsupials and monotremes

A.T. Whittington; A.L. Parkinson; P.B.S. Spencer; G. Grigg; L. Hinds; C.H. Gallagher; P.W. Kuchel; N.S. Agar

doi:10.1016/0742-8413(95)00009-D

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Comparative study of the antioxidant defence systems in the erythrocytes of australian marsupials and monotremes

Journal article

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Comparative study of the antioxidant defence systems in the erythrocytes of australian marsupials and monotremes

A.T. Whittington, A.L. Parkinson, P.B.S. Spencer, G. Grigg, L. Hinds, C.H. Gallagher, P.W. Kuchel and N.S. Agar

Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, Vol.110(3), pp.267-272

1995

DOI: https://doi.org/10.1016/0742-8413(95)00009-D

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Abstract

A comparison of the erythrocyte (RBC) antioxidant metabolites and enzymes in nine marsupial and two monotreme species was carried out. Reduced glutathione (GSH) concentrations were comparable with those reported for other marsupial and eutherian species. An important finding was that the erythrocytes of the southern hairy nosed wombat regenerated GSH faster than the erythrocytes from its close relative, the common wombat. The activities of glutathione-S-transferase, NADH-methaemoglobin reductase, Superoxide dismutase, and glutathione peroxidase (GSH-Px), showed similar levels and extents of variation as those observed in other marsupial and eutherian species. Catalase activities in the marsupials were lower than those measured in the two monotreme species and much lower than those reported in eutherian species. A negative correlation, significant at P < 0.05, was observed between GSH-Px and catalase activities in the RBC of the marsupials. Since both these enzymes "detoxify" H2O2, there appears to be a reciprocal relationship between the activities of these enzymes in marsupial RBC.

Details

Title: Comparative study of the antioxidant defence systems in the erythrocytes of australian marsupials and monotremes
Authors/Creators: A.T. Whittington (Author/Creator) - University of New England
A.L. Parkinson (Author/Creator) - University of New England
P.B.S. Spencer (Author/Creator)
G. Grigg (Author/Creator) - The University of Queensland
L. Hinds (Author/Creator) - Commonwealth Scientific and Industrial Research Organisation
C.H. Gallagher (Author/Creator) - The University of Sydney
P.W. Kuchel (Author/Creator) - The University of Sydney
N.S. Agar (Author/Creator) - University of New England
Publication Details: Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, Vol.110(3), pp.267-272
Publisher: Elsevier B.V.
Identifiers: 991005540788407891
Copyright: © 1995 Published by Elsevier Inc
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.225 Hematologic Diseases; 1.225.786 Erythrocyte Mechanics
Web Of Science research areas: Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology
ESI research areas: Biology & Biochemistry