Journal article
Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns
Pediatric Allergy and Immunology, Vol.23(2), pp.173-180
2011
Abstract
Background: Environmental changes, including declining microbial exposure, have been linked with the rising incidence of allergic and autoimmune diseases in ‘western’ populations. This potentially occurs by altering early development of immuno-regulatory pathways including T regulatory cells (Treg). There is now increasing evidence that such conditioning begins in utero.
Methods: We compared neonatal Treg from children born under typical western conditions (Australia, AUS) with those of neonates born under more traditional conditions of high microbial burden (Papua New Guinea, PNG).
Results: The frequency of neonatal Treg, defined as CD4+ Foxp3+ CD127− CD25+/high was found to be higher in the cord blood of AUS compared to PNG newborns. However, cord Tregsuppressive function in a small subset of children was qualitatively similar between PNG and AUS newborns in both a Treg depletion assay and a Treg supplementation assay.
Conclusions: These findings do not support the hypothesis that living in a ‘western’ versus more traditional environment leads to poor induction or suppressive function of neonatal Treg. However, environmentally-induced immuno-regulation may potentially occur via alternative mechanisms in PNG newborns that should now be investigated further.
Details
- Title
- Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns
- Authors/Creators
- J.G. Lisciandro (Author/Creator)S.L. Prescott (Author/Creator)M.G. Nadal-Sims (Author/Creator)C.J. Devitt (Author/Creator)W. Pomat (Author/Creator)P.M. Siba (Author/Creator)P.G. Holt (Author/Creator)D. Strickland (Author/Creator)A.H.J. van den Biggelaar (Author/Creator)
- Publication Details
- Pediatric Allergy and Immunology, Vol.23(2), pp.173-180
- Publisher
- Blackwell Publishing Inc.
- Identifiers
- 991005542655407891
- Copyright
- © 2011 John Wiley & Sons A/S
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
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- Citation topics
- 6 Social Sciences
- 6.73 Social Psychology
- 6.73.685 Item Response Theory
- Web Of Science research areas
- Allergy
- Immunology
- Pediatrics
- ESI research areas
- Immunology