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Journal article
Comparison of oral esomeprazole and oral omeprazole in the treatment of equine squamous gastric disease
Equine Veterinary Journal, Vol.56(5), pp.952-958
2023
Abstract
Background
Oral omeprazole is the accepted treatment for equine squamous gastric disease (ESGD); however, it is not universally effective. Esomeprazole results in more consistent and pronounced acid suppression in men and is more effective than omeprazole in the treatment of oesophageal and gastric disease. Pharmacodynamic and pilot clinical studies have indicated esomeprazole might also be more effective than omeprazole in horses.
Objectives
To compare the efficacy and safety of oral esomeprazole and omeprazole pastes in the treatment of ESGD and, where present, concurrent equine glandular gastric disease (EGGD).
Study design
Randomised, single-blinded controlled trial.
Methods
Horses presenting with grade ≥2 ESGD lesions were randomly allocated to receive 4 mg/kg of either a buffered esomeprazole or omeprazole paste orally once daily for 28 days before gastroscopy being repeated within a further 3 days. Videos and images were anonymised and subsequently graded blind by one researcher. The severity of ESGD (and EGGD) lesions before and after treatment, and thereby treatment responses, were compared using univariable logistic regression.
Results
A higher proportion of horses had ESGD healing in response to esomeprazole treatment (63/74, 85%) than with omeprazole treatment (43/73, 59%) (odds ratio [OR]: 4.00, 95% confidence interval [CI]: 1.81, 8.82, p = 0.001). In a subset of horses that had concurrent EGGD, a greater proportion of the horses treated with esomeprazole had lesions ≤grade 1 (esomeprazole 28/51, 55%; omeprazole 6/24, 25%; OR: 3.65, 95% CI: 1.25, 10.71, p = 0.02) Using grade 0 as the benchmark for EGGD healing, the difference remained significant (OR: 4.44, 95% CI: 1.33, 14.85, p = 0.02).
Main limitations
It may not be possible to extrapolate these results to other populations with different signalment or management.
Conclusions
Oral-buffered esomeprazole was a more effective treatment for ESGD (and concurrent EGGD) than oral-buffered omeprazole.
Details
- Title
- Comparison of oral esomeprazole and oral omeprazole in the treatment of equine squamous gastric disease
- Authors/Creators
- Tania Sundra - Avon (United States)Sarah Gough - Hunter Equine Centre Scone New South Wales AustraliaGabriele Rossi - Murdoch UniversityErin Kelty - The University of Western AustraliaDavid Rendle - EMT Consulting Devon UK
- Publication Details
- Equine Veterinary Journal, Vol.56(5), pp.952-958
- Publisher
- John Wiley & Sons Ltd on behalf of EVJ Ltd.
- Identifiers
- 991005605568307891
- Copyright
- © 2023 The Authors.
- Murdoch Affiliation
- School of Veterinary Medicine; Centre for Animal Production and Health
- Language
- English
- Resource Type
- Journal article
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- 3 Agriculture, Environment & Ecology
- 3.232 Veterinary Sciences
- 3.232.1936 Equine and Bovine Gastrointestinal Disorders
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