Journal article
Complement-mediated muscle cell lysis: A possible mechanism of myonecrosis in anti-SRP associated necrotizing myopathy (ASANM)
Journal of Neuroimmunology, Vol.264(1-2), pp.65-70
2013
Abstract
The mechanism of necrotizing myopathy associated with antibodies to signal recognition particle (SRP) remains unclear. We investigated the effect of anti-SRP + serum and complement on cell viability in myoblast cultures. Cell viability was only slightly reduced by incubation with anti-SRP + serum compared with control serum. However, the addition of fresh complement resulted in a marked reduction in cell survival. Surface immunostaining for SRP, C3c and C5b-9 was demonstrated in cultures pre-incubated with anti-SRP + serum and complement, and in muscle biopsies from patients with myopathy. These findings provide further support for a complement-dependent antibody-mediated mechanism in anti-SRP associated myopathy.
Details
- Title
- Complement-mediated muscle cell lysis: A possible mechanism of myonecrosis in anti-SRP associated necrotizing myopathy (ASANM)
- Authors/Creators
- A. Rojana-udomsart (Author/Creator) - The University of Western AustraliaC. Mitrpant (Author/Creator) - Siriraj HospitalC. Bundell (Author/Creator) - The University of Western AustraliaL. Price (Author/Creator) - The University of Western AustraliaY-B Luo (Author/Creator) - The University of Western AustraliaV. Fabian (Author/Creator) - Royal Perth HospitalS.D. Wilton (Author/Creator) - The University of Western AustraliaP. Hollingsworth (Author/Creator) - The University of Western AustraliaF.L. Mastaglia (Author/Creator) - The University of Western Australia
- Publication Details
- Journal of Neuroimmunology, Vol.264(1-2), pp.65-70
- Publisher
- Elsevier
- Identifiers
- 991005540215307891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.1684 Dermatomyositis
- Web Of Science research areas
- Immunology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior