Complete coding regions of two novel HLA-B alleles detected by prototyping (PCR-SSP) in the British Caucasoid population: B*5108 and B*5002

C. Vilches; M. Bunce; R. Pablo; A.K. Murray; C.A. McIntyre; M. Kreisler

doi:10.1111/j.1399-0039.1997.tb02831.x

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Complete coding regions of two novel HLA-B alleles detected by prototyping (PCR-SSP) in the British Caucasoid population: B*5108 and B*5002

Journal article

Peer reviewed

Complete coding regions of two novel HLA-B alleles detected by prototyping (PCR-SSP) in the British Caucasoid population: B5108 and B5002

C. Vilches, M. Bunce, R. Pablo, A.K. Murray, C.A. McIntyre and M. Kreisler

Tissue Antigens, Vol.50(1), pp.38-41

1997

DOI: https://doi.org/10.1111/j.1399-0039.1997.tb02831.x

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Abstract

Two previously reported PCR-SSP variants of the HLA-B locus, B51GAC and B45v, were investigated by RT-PCR cloning and nucleotide sequence analysis of their complete coding regions. They have been shown to correspond to the new alleles B*5108 and B*5002, both of which differ from the common B*5101 and B*5001 subtypes, respectively, by amino acid replacements at their α-2 domain α-helices. The primary structure of B*5002, intermediate between those of B*4501 and B*5001, raises further concern about the current classification of B*45 as a B12 rather than as a B*50 subtype.

Details

Title: Complete coding regions of two novel HLA-B alleles detected by prototyping (PCR-SSP) in the British Caucasoid population: B*5108 and B*5002
Authors/Creators: C. Vilches (Author/Creator) - Servicio de Inmunologia, Cllnica Puerta de Hierro, Madrid, Spain
M. Bunce (Author/Creator) - Churchill Hospital
R. Pablo (Author/Creator)
A.K. Murray (Author/Creator) - University of Sheffield
C.A. McIntyre (Author/Creator) - University of Sheffield
M. Kreisler (Author/Creator) - Servicio de Inmunologia, Cllnica Puerta de Hierro, Madrid, Spain
Publication Details: Tissue Antigens, Vol.50(1), pp.38-41
Publisher: Blackwell Publishing
Identifiers: 991005544560707891
Copyright: 1997 Munksgaard
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.607 MHC Diversity
Web Of Science research areas: Cell Biology; Immunology; Pathology
ESI research areas: Molecular Biology & Genetics