Journal article
Complications associated with NRTI therapy: Update on clinical features and possible pathogenic mechanisms
Antiviral Therapy, Vol.9(6), pp.849-863
2004
Abstract
The availability of durable, effective antiretroviral therapy for HIV-infected patients has fundamentally altered the prognosis of this disease and has also increased awareness that long-term drug toxicities have the potential to cause significant morbidity and even mortality in this patient population. The long-term use of nucleoside analogue reverse transcriptase inhibitor (NRTI) drugs has been associated with a number of clinically relevant toxicities including hyperlactataemia and lactic acidosis, neuropathy, pancreatitis and, more recently, a syndrome of pathological loss of subcutaneous fat tissue (lipoatrophy). Importantly, the toxicity profile of each NRTI drug within this class is unique in terms of the overall risk of long-term complications, as well as the tissue specificity of its toxic effects. In this review, the clinical manifestations, risk factors and pathological basis for NRTI-associated toxicity syndromes are explored, with an emphasis on clinical assessment and management.
Details
- Title
- Complications associated with NRTI therapy: Update on clinical features and possible pathogenic mechanisms
- Authors/Creators
- D. Nolan (Author/Creator)S. Mallal (Author/Creator)
- Publication Details
- Antiviral Therapy, Vol.9(6), pp.849-863
- Publisher
- International Medical Press
- Identifiers
- 991005543317907891
- Copyright
- © 2004 International Medical Press
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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