Compression socks and the effects on coagulation and fibrinolytic activation during marathon running

E.K. Zadow; M.J. Adams; S.S.X. Wu; C.M. Kitic; I. Singh; A. Kundur; N. Bost; A.N.B. Johnston; J. Crilly; A.C. Bulmer; S.L. Halson; J.W. Fell

doi:10.1007/s00421-018-3929-5

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Compression socks and the effects on coagulation and fibrinolytic activation during marathon running

Journal article

Peer reviewed

Compression socks and the effects on coagulation and fibrinolytic activation during marathon running

E.K. Zadow, M.J. Adams, S.S.X. Wu, C.M. Kitic, I. Singh, A. Kundur, N. Bost, A.N.B. Johnston, J. Crilly, A.C. Bulmer, …

European Journal of Applied Physiology, Vol.118(10), pp.2171-2177

2018

DOI: https://doi.org/10.1007/s00421-018-3929-5

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Abstract

Purpose: Compression socks are frequently used in the treatment and prevention of lower-limb pathologies; however, when combined with endurance-based exercise, the impact of compression socks on haemostatic activation remains unclear. Objectives: To investigate the effect of wearing compression socks on coagulation and fibrinolysis following a marathon. Methods: Sixty-seven participants [43 males (mean ± SD: age: 46.7 ± 10.3 year) and 24 females (age: 40.0 ± 11.0 year)] were allocated into a compression (SOCK, n = 34) or control (CONTROL, n = 33) group. Venous blood samples were obtained 24 h prior to and immediately POST-marathon, and were analyzed for thrombin–anti-thrombin complex (TAT), tissue factor (TF), tissue factor pathway inhibitor (TFPI), and D-Dimer. Results: Compression significantly attenuated the post-exercise increase in D-Dimer compared to the control group [median (range) SOCK: + 9.02 (− 0.34 to 60.7) ng/mL, CONTROL: + 25.48 (0.95–73.24) ng/mL]. TF increased following the marathon run [median (range), SOCK: + 1.19 (− 7.47 to 9.11) pg/mL, CONTROL: + 3.47 (− 5.01 to 38.56) pg/mL] in all runners. No significant post-exercise changes were observed for TAT and TFPI. Conclusions: While activation of coagulation and fibrinolysis was apparent in all runners POST-marathon, wearing compression socks was shown to reduce fibrinolytic activity, as demonstrated by lower D-Dimer concentrations. Compression may reduce exercise-associated haemostatic activation when completing prolonged exercise.

Details

Title: Compression socks and the effects on coagulation and fibrinolytic activation during marathon running
Authors/Creators: E.K. Zadow (Author/Creator) - University of Tasmania
M.J. Adams (Author/Creator) - University of Tasmania
S.S.X. Wu (Author/Creator) - Swinburne University of Technology
C.M. Kitic (Author/Creator) - University of Tasmania
I. Singh (Author/Creator) - Griffith University
A. Kundur (Author/Creator) - Griffith University
N. Bost (Author/Creator) - Griffith University
A.N.B. Johnston (Author/Creator) - Griffith University
J. Crilly (Author/Creator) - Griffith University
A.C. Bulmer (Author/Creator) - Griffith University
S.L. Halson (Author/Creator) - Australian Institute of Sport
J.W. Fell (Author/Creator) - University of Tasmania
Publication Details: European Journal of Applied Physiology, Vol.118(10), pp.2171-2177
Publisher: Springer Verlag
Identifiers: 991005542169107891
Copyright: © 2018 Springer-Verlag GmbH Germany, part of Springer Nature
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.75 Blood Clotting; 1.75.966 Plasminogen Activation
Web Of Science research areas: Physiology; Sport Sciences
ESI research areas: Clinical Medicine