Journal article
Computational model for the analysis of cartilage and cartilage tissue constructs
Journal of Tissue Engineering and Regenerative Medicine, Vol.10(4), pp.334-347
2013
Abstract
We propose a new non-linear poroelastic model that is suited to the analysis of soft tissues. In this paper the model is tailored to the analysis of cartilage and the engineering design of cartilage constructs. The proposed continuum formulation of the governing equations enables the strain of the individual material components within the extracellular matrix (ECM) to be followed over time, as the individual material components are synthesized, assembled and incorporated within the ECM or lost through passive transport or degradation. The material component analysis developed here naturally captures the effect of time-dependent changes of ECM composition on the deformation and internal stress states of the ECM. For example, it is shown that increased synthesis of aggrecan by chondrocytes embedded within a decellularized cartilage matrix initially devoid of aggrecan results in osmotic expansion of the newly synthesized proteoglycan matrix and tension within the structural collagen network. Specifically, we predict that the collagen network experiences a tensile strain, with a maximum of ~2% at the fixed base of the cartilage. The analysis of an example problem demonstrates the temporal and spatial evolution of the stresses and strains in each component of a self-equilibrating composite tissue construct, and the role played by the flux of water through the tissue.
Details
- Title
- Computational model for the analysis of cartilage and cartilage tissue constructs
- Authors/Creators
- D.W. Smith (Author/Creator) - The University of Western AustraliaB.S. Gardiner (Author/Creator) - The University of Western AustraliaJ.B. Davidson (Author/Creator) - The University of Western AustraliaA.J. Grodzinsky (Author/Creator) - Massachusetts Institute of Technology
- Publication Details
- Journal of Tissue Engineering and Regenerative Medicine, Vol.10(4), pp.334-347
- Publisher
- Wiley
- Identifiers
- 991005540853307891
- Copyright
- © 2013 John Wiley & Sons, Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.34 Orthopedics
- 1.34.255 Osteoarthritis
- Web Of Science research areas
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- Cell & Tissue Engineering
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- ESI research areas
- Molecular Biology & Genetics