Journal article
Concordance between cerebrospinal fluid biomarkers with Alzheimer’s disease pathology between three independent assay platforms
Journal of Alzheimer's disease : JAD, Vol.61(1), pp.169-183
2017
Abstract
Background:To enhance the accuracy of clinical diagnosis for Alzheimer’s disease (AD), pre-mortem biomarkers have become increasingly important for diagnosis and for participant recruitment in disease-specific treatment trials. Cerebrospinal fluid (CSF) biomarkers provide a low-cost alternative to positron emission tomography (PET) imaging for in vivo quantification of different AD pathological hallmarks in the brains of affected subjects; however, consensus around the best platform, most informative biomarker and correlations across different methodologies are controversial. Objective:Assessing levels of Aβ-amyloid and tau species determined using three different versions of immunoassays, the current study explored the ability of CSF biomarkers to predict PET Aβ-amyloid (32 Aβ-amyloid–and 45 Aβ-amyloid+), as well as concordance between CSF biomarker levels and PET Aβ-amyloid imaging. Methods:Prediction and concordance analyses were performed using a sub-cohort of 77 individuals (48 healthy controls, 15 with mild cognitive impairment, and 14 with AD) from the Australian Imaging Biomarker and Lifestyle study of aging. Results:Across all three platforms, the T-tau/Aβ42 ratio biomarker had modestly higher correlation with SUVR/BeCKeT (ρ= 0.69–0.8) as compared with Aβ42 alone (ρ= 0.66–0.75). Differences in CSF biomarker levels between the PET Aβ-amyloid–and Aβ-amyloid+ groups were strongest for the Aβ42/Aβ40 and T-tau/Aβ42 ratios (p < 0.0001); however, comparison of predictive models for PET Aβ-amyloid showed no difference between Aβ42 alone and the T-tau/Aβ42 ratio. Conclusion:This study confirms strong concordance between CSF biomarkers and PET Aβ-amyloid status is independent of immunoassay platform, supporting their utility as biomarkers in clinical practice for the diagnosis of AD and for participant enrichment in clinical trials.
Details
- Title
- Concordance between cerebrospinal fluid biomarkers with Alzheimer’s disease pathology between three independent assay platforms
- Authors/Creators
- J.D. Doecke (Author/Creator) - Cooperative Research Centre for Mental HealthA. Rembach (Author/Creator) - Florey Institute of Neuroscience and Mental HealthV.L. Villemagne (Author/Creator) - Florey Institute of Neuroscience and Mental HealthS. Varghese (Author/Creator) - Florey Institute of Neuroscience and Mental HealthS. Rainey-Smith (Author/Creator)S. Sarros (Author/Creator) - Florey Institute of Neuroscience and Mental HealthL.A. Evered (Author/Creator) - St Vincent's HealthC.J. Fowler (Author/Creator) - Florey Institute of Neuroscience and Mental HealthK.K. Pertile (Author/Creator) - Florey Institute of Neuroscience and Mental HealthR.L. Rumble (Author/Creator) - Florey Institute of Neuroscience and Mental HealthB. Trounson (Author/Creator) - Florey Institute of Neuroscience and Mental HealthK. Taddei (Author/Creator) - Hollywood Private HospitalS.M. Laws (Author/Creator) - Hollywood Private HospitalS.L. Macaulay (Author/Creator) - CSIRO Health and BiosecurityA.I. Bush (Author/Creator) - Florey Institute of Neuroscience and Mental HealthK.A. Ellis (Author/Creator) - The University of MelbourneR. Martins (Author/Creator) - Hollywood Private HospitalD. Ames (Author/Creator) - The University of MelbourneB. Silbert (Author/Creator) - St Vincent's HealthH. Vanderstichele (Author/Creator) - ADx NeuroSciencesC.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental HealthD.G. Darby (Author/Creator) - Florey Institute of Neuroscience and Mental HealthQ-X Li (Author/Creator) - Florey Institute of Neuroscience and Mental HealthS. Collins (Author/Creator) - The University of MelbourneH.B. Kuiperij (Author/Creator)
- Publication Details
- Journal of Alzheimer's disease : JAD, Vol.61(1), pp.169-183
- Publisher
- IOS Press
- Identifiers
- 991005543221907891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior