Journal article
Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase
Bioorganic & Medicinal Chemistry Letters, Vol.18(2), pp.460-463
2008
Abstract
Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and a potential antibiotic target. The enzyme catalyses the condensation of (S)-aspartate semi-aldehyde (ASA) and pyruvate to form dihydrodipicolinate. Constrained diketopimelic acid derivatives have been designed as mimics of the acyclic enzyme-bound condensation product of ASA and pyruvate. Several of the compounds are shown to be active, slow-binding inhibitors with improved inhibition of DHDPS.
Details
- Title
- Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase
- Authors/Creators
- B.A. Boughton (Author/Creator)R.C.J. Dobson (Author/Creator)J.A. Gerrard (Author/Creator)C.A. Hutton (Author/Creator)
- Publication Details
- Bioorganic & Medicinal Chemistry Letters, Vol.18(2), pp.460-463
- Publisher
- Elsevier
- Identifiers
- 991005545425807891
- Copyright
- © 2007 Elsevier Ltd
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.180 Microbial Biotechnology
- 3.180.1184 Amino Acid Biosynthesis
- Web Of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic
- ESI research areas
- Chemistry