Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report

H. Hamamy; S.E. Antonarakis; L.L. Cavalli-Sforza; S. Temtamy; G. Romeo; L.P. Ten Kate; R.L. Bennett; A. Shaw; A. Megarbane; C. van Duijn; H. Bathija; S. Fokstuen; E. Engel; J. Zlotogora; E. Dermitzakis; A. Bottani; S. Dahoun; M.A. Morris; S. Arsenault; M.S. Aglan; M. Ajaz; A. Alkalamchi; D. Alnaqeb; M.K. Alwasiyah; N. Anwer; R. Awwad; M. Bonnefin; P. Corry; L. Gwanmesia; G.A. Karbani; M. Mostafavi; T. Pippucci; E. Ranza-Boscardin; B. Reversade; S.M. Sharif; M.E. Teeuw; A.H. Bittles

doi:10.1097/GIM.0b013e318217477f

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Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report

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Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report

H. Hamamy, S.E. Antonarakis, L.L. Cavalli-Sforza, S. Temtamy, G. Romeo, L.P. Ten Kate, R.L. Bennett, A. Shaw, A. Megarbane, C. van Duijn, …

Genetics in Medicine, Vol.13(9), pp.841-847

2011

DOI: https://doi.org/10.1097/GIM.0b013e318217477f

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Abstract

Approximately 1.1 billion people currently live in countries where consanguineous marriages are customary, and among them one in every three marriages is between cousins. Opinions diverge between those warning of the possible health risks to offspring and others who highlight the social benefits of consanguineous marriages. A consanguinity study group of international experts and counselors met at the Geneva International Consanguinity Workshop from May 3 2010, to May 7, 2010, to discuss the known and presumptive risks and benefits of close kin marriages and to identify important future areas for research on consanguinity. The group highlighted the importance of evidence-based counseling recommendations for consanguineous marriages and of undertaking both genomic and social research in defining the various influences and outcomes of consanguinity. Technological advances in rapid high-throughput genome sequencing and for the identification of copy number variants by comparative genomic hybridization offer a significant opportunity to identify genotype-phenotype correlations focusing on autozygosity, the hallmark of consanguinity. The ongoing strong preferential culture of close kin marriages in many societies, and among migrant communities in Western countries, merits an equivalently detailed assessment of the social and genetic benefits of consanguinity in future studies.

Details

Title: Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report
Authors/Creators: H. Hamamy (Author/Creator) - University of Geneva
S.E. Antonarakis (Author/Creator) - University of Geneva
L.L. Cavalli-Sforza (Author/Creator) - University of Pavia
S. Temtamy (Author/Creator) - National Research Centre
G. Romeo (Author/Creator) - University of Bologna
L.P. Ten Kate (Author/Creator)
R.L. Bennett (Author/Creator) - University of Washington Medical Center
A. Shaw (Author/Creator) - University of Oxford
A. Megarbane (Author/Creator) - Saint Joseph's University
C. van Duijn (Author/Creator) - Department of Epidemiology and Biostatistics, Erasmus University Medical School, Erasmusmc, Rotterdam, The Netherlands
H. Bathija (Author/Creator) - World Health Organization
S. Fokstuen (Author/Creator) - University of Geneva
E. Engel (Author/Creator) - University of Geneva
J. Zlotogora (Author/Creator) - Israel Ministry of Health
E. Dermitzakis (Author/Creator) - University of Geneva
A. Bottani (Author/Creator) - University of Geneva
S. Dahoun (Author/Creator) - University of Geneva
M.A. Morris (Author/Creator) - University Hospital of Geneva
S. Arsenault (Author/Creator) - Génome Québec and Ecogene-21 Biobank, Chicoutimi, Canada
M.S. Aglan (Author/Creator) - National Research Centre
M. Ajaz (Author/Creator) - University of Bedfordshire
A. Alkalamchi (Author/Creator) - PHC Department/Ministry of Health, Mental Health Section, Baghdad, Iraq
D. Alnaqeb (Author/Creator) - King Saud University
M.K. Alwasiyah (Author/Creator) - Aziziah Maternity and Children Hospital, Ministry of Health, Jeddah, Saudi Arabia
N. Anwer (Author/Creator) - Baghdad Medical City
R. Awwad (Author/Creator) - Hadassah Medical Center
M. Bonnefin (Author/Creator) - King's College London
P. Corry (Author/Creator)
L. Gwanmesia (Author/Creator) - University of Geneva
G.A. Karbani (Author/Creator) - Leeds Teaching Hospitals NHS Trust
M. Mostafavi (Author/Creator) - University of Geneva
T. Pippucci (Author/Creator) - IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola
E. Ranza-Boscardin (Author/Creator) - University of Geneva
B. Reversade (Author/Creator) - Institute of Medical Biology
S.M. Sharif (Author/Creator) - Chapel Allerton Hospital
M.E. Teeuw (Author/Creator) - Amsterdam UMC Location Vrije Universiteit Amsterdam
A.H. Bittles (Author/Creator) - Edith Cowan University
Publication Details: Genetics in Medicine, Vol.13(9), pp.841-847
Publisher: Lippincott Williams & Wilkins
Identifiers: 991005542254007891
Copyright: © 2011 The American College of Medical Genetics
Murdoch Affiliation: Centre for Comparative Genomics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.189 Genome Studies; 1.189.1853 Human Genetic Diversity
Web Of Science research areas: Genetics & Heredity
ESI research areas: Clinical Medicine