Consanguinity and pregnancy outcomes in a multi-ethnic, metropolitan European population

R. Becker; T. Keller; R-D Wegner; H. Neitzel; M. Stumm; U. Knoll; M. Stärk; H. Fangerau; A. Bittles

doi:10.1002/pd.4487

Back

Consanguinity and pregnancy outcomes in a multi-ethnic, metropolitan European population

Journal article

Open access

Peer reviewed

Consanguinity and pregnancy outcomes in a multi-ethnic, metropolitan European population

R. Becker, T. Keller, R-D Wegner, H. Neitzel, M. Stumm, U. Knoll, M. Stärk, H. Fangerau and A. Bittles

Prenatal Diagnosis, Vol.35(1), pp.81-89

2015

DOI: https://doi.org/10.1002/pd.4487

Files and links (2)

pdf

consanguinity_and_pregnancy.pdfDownload View

Author’s Version Open Access

url

Link to Published Version *Subscription may be requiredView

Abstract

Objective The aim of the present study was to assess the risk of major anomalies in the offspring of consanguineous couples, including data on the prenatal situation. Methods Over 20 years (1993–2012), 35 391 fetuses were examined by prenatal sonography. In 675 cases (1.9%), parents were consanguineous, with 307 couples (45.5%) related as first cousins, 368 couples (54.5%) beyond first cousins. Detailed information was retrieved on 31 710 (89.6%) fetuses, (consanguineous 568: 1.8%). Results Overall prevalence of major anomalies among fetuses with non-consanguineous parents was 2.9% (consanguineous, 10.9%; first cousins, 12.4%; beyond first cousins, 6.5%). Adjusting the overall numbers for cases having been referred because of a previous index case, the prevalences were 2.8% (non-consanguineous) and 6.1% (consanguineous) (first cousin, 8.5%; beyond first cousin, 3.9%). Further adjustment for differential rates of trisomic pregnancies indicated 2.0%/5.9% congenital anomalies (non-consanguineous/consanguineous groups), that is, a consanguinity-associated excess of 3.9%, 6.1% in first cousin progeny and 1.9% beyond first cousin. Conclusions The prevalence of major fetal anomalies associated with consanguinity is higher than in evaluations based only on postnatal life. It is important that this information is made available in genetic counselling programmes, especially in multi-ethnic and multi-religious communities, to enable couples to make informed decisions.

Details

Title: Consanguinity and pregnancy outcomes in a multi-ethnic, metropolitan European population
Authors/Creators: R. Becker (Author/Creator) - Center for Human Genetics
T. Keller (Author/Creator) - Acomed Statistics Leipzig Germany
R-D Wegner (Author/Creator) - Center for Human Genetics
H. Neitzel (Author/Creator) - Charité - Universitätsmedizin Berlin
M. Stumm (Author/Creator) - Center for Human Genetics
U. Knoll (Author/Creator) - Center for Human Genetics
M. Stärk (Author/Creator) - Center for Human Genetics
H. Fangerau (Author/Creator) - Universität Ulm
A. Bittles (Author/Creator) - Murdoch University
Publication Details: Prenatal Diagnosis, Vol.35(1), pp.81-89
Publisher: John Wiley & Sons, Ltd.
Identifiers: 991005540876207891
Copyright: © 2014 John Wiley & Sons, Ltd.
Murdoch Affiliation: Centre for Comparative Genomics
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

848 File views/ downloads

170 Record Views

20 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.189 Genome Studies; 1.189.1853 Human Genetic Diversity
Web Of Science research areas: Genetics & Heredity; Obstetrics & Gynecology
ESI research areas: Clinical Medicine