Consensus report of the Working Group on: "Molecular and Biochemical Markers of Alzheimer's Disease"

Peter Davies; Judith Resnick; Burton Resnick; Sid Gilman; John Growdon; Zaven S. Khachaturian; Teresa S. Radebaugh; Allen D. Roses; Dennis J. Selkoe; John Q. Trojanowski; John P. Blass; Gary E. Gibson; K.-F.R. Sheu; Kaj Blennow; Andre Delacourte; Giovanni B. Frisoni; Wilfred A. Jefferies; Amanda McRae; H.M. Wisniewski; P.D. Mehta; T. Pirttla; Ram Parshad; Leonard F. M. Scinto; Philip Scheltens; Paavo J. Riekkinen; Hilkka S. Soininen; Gregory R. J. Swanwick; Lars-Olof Wahlund; S.E. Arnold; Bengt Winblad; Yasuo Ihara; Tsuneo Yamazaki; Hiroyuki Arai; Christopher M. Clark; Douglas C. Ewbank; Sadao Takase; Susumu Higuchi; Masakazu Mirua; Hisatomo Seki; Makoto Higuchi; Toshifumi Matsui; Virginia M.-Y Lee; Hidetata Sasaki; Norman L. Foster; Douglas Galasko; Christoph Hock; Bradley T. Hyman; P.H. St. George-Hyslop; Takeshi Iwatsubo; Malcolm Kennard; William E. Klunk; Lars Lannfelt; Irene Litvan; Richard Mayeux; Alfredo Robles; V.A. Fabian; T.M. Jones; S.D. Wilton; J.E. Dench; M.R. Davis; L. Lim; B.A. Kakulas; M.L. Kennard; H. Feldman; T. Yamada; R.A. Sweet; G.S. Zubenko; Alzheimers Assoc

doi:10.1016/S0197-4580(98)00022-0

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Consensus report of the Working Group on: "Molecular and Biochemical Markers of Alzheimer's Disease"

Journal article

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Consensus report of the Working Group on: "Molecular and Biochemical Markers of Alzheimer's Disease"

Peter Davies, Judith Resnick, Burton Resnick, Sid Gilman, John Growdon, Zaven S. Khachaturian, Teresa S. Radebaugh, Allen D. Roses, Dennis J. Selkoe, John Q. Trojanowski, …

Neurobiology of aging, Vol.19(2), pp.109-116

1998

DOI: https://doi.org/10.1016/S0197-4580(98)00022-0

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Abstract

Geriatrics & Gerontology

Life Sciences & Biomedicine

Neurosciences

Neurosciences & Neurology

Science & Technology

The ideal biomarker for Alzheimer's disease (AD) should detect a fundamental feature of neuropathology and be validatrd in neuropathologically-confirmed cases; it should have a sensitivity >80% for detecting AD and a specificity of >80% for distinguishing other dementias; it should be reliable, reproducible, non-invasive, simple to perform, and inexpensive. Recommended steps to establish a biomarker include confirmation by at least two independent studies conducted by qualified investigators with the results published in peer-reviewed journals. Our review of current candidate markers indicates that for suspected early-onset familial AD, it is appropriate to search fur mutations in the presenilin 1, presenilin 2, and amyloid precursor protein genes. Individuals with these mutations typically have increased levels of the amyloid A beta(42) peptide in plasma and decreased levels of APPs in cerebrospinal fluid. In late-onset and sporadic AD, these measures are nor useful, but detecting an apolipoprotein E el allele can add confidence to the clinical diagnosis. Among the other proposed molecular and biochemical markers for sporadic AD, cerebrospinal fluid assays showing low levels of A beta(42) and high levels of tau come closest to fulfilling criteria for a useful biomarker.

Details

Title: Consensus report of the Working Group on: "Molecular and Biochemical Markers of Alzheimer's Disease"
Authors/Creators: Peter Davies - Yeshiva University
Judith Resnick - Yeshiva University
Burton Resnick - Yeshiva University
Sid Gilman - University of Michigan
John Growdon - Harvard University
Zaven S. Khachaturian - Alzheimer's Association
Teresa S. Radebaugh - Alzheimer's Association
Allen D. Roses - GlaxoSmithKline (United Kingdom)
Dennis J. Selkoe - Harvard University
John Q. Trojanowski - University of Michigan
John P. Blass - Cornell University
Gary E. Gibson - Cornell University
K.-F.R. Sheu - Cornell University
Kaj Blennow - Medical Research Council
Andre Delacourte - Inserm
Giovanni B. Frisoni - Geriatric Research Group, Istituto, Sacro Cuore di Gesu
Wilfred A. Jefferies - University of British Columbia
Amanda McRae - University of Gothenburg
H.M. Wisniewski - New York Stt. Inst. for Basic R
P.D. Mehta - New York Stt. Inst. for Basic R
T. Pirttla - New York Stt. Inst. for Basic R
Ram Parshad - Howard University
Leonard F. M. Scinto - Brigham and Women's Hospital
Philip Scheltens - Vrije Universiteit Amsterdam
Paavo J. Riekkinen - University of Eastern Finland
Hilkka S. Soininen - University of Eastern Finland
Gregory R. J. Swanwick - Trinity College Dublin
Lars-Olof Wahlund - Karolinska Institutet
S.E. Arnold - University of Pennsylvania
Bengt Winblad - Karolinska Institutet
Yasuo Ihara - The University of Tokyo
Tsuneo Yamazaki - The University of Tokyo
Hiroyuki Arai - Tohoku University
Christopher M. Clark - Tohoku University
Douglas C. Ewbank - Tohoku University
Sadao Takase - Tohoku University
Susumu Higuchi - Tohoku University
Masakazu Mirua - Tohoku University
Hisatomo Seki - Tohoku University
Makoto Higuchi - Tohoku University
Toshifumi Matsui - Tohoku University
Virginia M.-Y Lee - Tohoku University
Hidetata Sasaki - Tohoku University
Norman L. Foster - University of Michigan
Douglas Galasko - University of California San Diego
Christoph Hock - University of Basel
Bradley T. Hyman - Harvard University
P.H. St. George-Hyslop - University of Toronto
Takeshi Iwatsubo - The University of Tokyo
Malcolm Kennard - University of British Columbia
William E. Klunk - University of Pittsburgh
Lars Lannfelt - Karolinska Institutet
Irene Litvan - National Institutes of Health
Richard Mayeux - Columbia University
Alfredo Robles - Universidade de Santiago de Compostela
V.A. Fabian
T.M. Jones
S.D. Wilton
J.E. Dench
M.R. Davis
L. Lim
B.A. Kakulas
M.L. Kennard - University of British Columbia
H. Feldman
T. Yamada
R.A. Sweet
G.S. Zubenko
Alzheimers Assoc
Publication Details: Neurobiology of aging, Vol.19(2), pp.109-116
Publisher: Elsevier
Number of pages: 8
Identifiers: 991005592758507891
Murdoch Affiliation: Centre for Molecular Medicine and Innovative Therapeutics
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Geriatrics & Gerontology; Neurosciences
ESI research areas: Neuroscience & Behavior