Logo image
Back
Consumption of a whey protein-enriched diet may prevent hepatic steatosis associated with weight gain in elderly women
Journal article   Peer reviewed

Consumption of a whey protein-enriched diet may prevent hepatic steatosis associated with weight gain in elderly women

E.M. Ooi, L.A. Adams, K. Zhu, J.R. Lewis, D.A. Kerr, X. Meng, V. Solah, A. Devine, C.W. Binns and R.L. Prince
Nutrition, Metabolism and Cardiovascular Diseases, Vol.25(4), pp.388-395
2015
DOI: https://doi.org/10.1016/j.numecd.2014.11.005
url
Link to Published Version *Subscription may be requiredView

Abstract

Background and aims Protein consumption has been associated with cardio-metabolic benefits, including weight loss and improved insulin sensitivity, and may have potential benefits for individuals with fatty liver disease (FLD). We investigated the effect of increasing dietary protein intake from whey relative to carbohydrate on hepatic steatosis. Methods and results A two-year randomized, double-blind, placebo-controlled trial of 30 g/day whey protein-supplemented beverage (protein) or an energy-matched low-protein high-carbohydrate beverage (control) for cardio-metabolic and bone health in 219 healthy elderly women, recruited from the Western Australian general population. Hepatic steatosis was quantified using computed tomographic liver-to-spleen (L/S) ratio. FLD was defined as liver-to-spleen difference <10 Hounsfield units. At baseline, FLD prevalence was 11.4%. Control and protein groups were similar in body mass index (BMI), insulin resistance, L/S ratio and FLD prevalence at baseline. At two-years, dietary protein increased by 20 g in the protein, but not the control, group. Total energy intake and physical activity remained similar between groups. At two-years, BMI and FLD prevalence increased in both groups, with no between group differences. L/S ratio increased in control, but not protein, group at two-years, with no between group differences. In a within group comparison, change in BMI correlated with changes in L/S ratio in control ( r = 0.37, P = 0.0007), but not with protein group ( r = 0.04, P = 0.73). Conclusion Increasing dietary protein intake from whey relative to carbohydrate does not reduce weight, hepatic steatosis or the prevalence of FLD in elderly women. However, it may prevent worsening of hepatic steatosis associated with weight gain.

Details

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

Metrics

19 Record Views
14 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.125 Hepatitis
1.125.663 NAFLD
Web Of Science research areas
Cardiac & Cardiovascular Systems
Endocrinology & Metabolism
Nutrition & Dietetics
ESI research areas
Clinical Medicine
Logo image