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CC BY V4.0, Open Access
Journal article
Contribution of Animal Models to Contemporary Understanding of Attention Deficit Hyperactivity Disorder
ALTEX, alternatives to animal experimentation, Vol.33(3), pp.243-249
2016
PMID: 26963673
Abstract
Attention Deficit Hyperactivity Disorder (ADHD) is a poorly understood neurodevelopmental disorder of multifactorial origin. Animal-based research has been used to investigate ADHD etiology, pathogenesis and treatment, but the efficacy of this research for patients has not yet been systematically evaluated. Such evaluation is important given the resource consumption and ethical concerns incurred by animal use.
We used the citation tracking facility within Web of Science to locate citations of original research papers on animal models related to ADHD published prior to 2010 identified in PubMed by relevant search terms. Human medical papers citing those animal studies were carefully analyzed by two independent raters to evaluate the contribution of the animal data to the human studies.
211 publications describing relevant animal studies were located. Approximately half (3,342) of their 6,406 citations were by other animal studies. 446 human medical papers cited 121 of these 211 animal studies, a total of 500 times. 254 of these 446 papers were human studies of ADHD. However, only eight of the cited animal papers (cited 10 times) were relevant to the hypothesis of the human medical study in question. Three of these eight papers described results from both human and animal studies, but their citations solely referred to the human data. Five animal research papers were relevant to the hypotheses of the applicable human medical papers.
Citation analysis indicates that animal research has contributed very little to contemporary understanding of ADHD. To ensure optimal allocation of Research & Development funds targeting this disorder the contribution of other research methods should be similarly evaluated.
Details
- Title
- Contribution of Animal Models to Contemporary Understanding of Attention Deficit Hyperactivity Disorder
- Authors/Creators
- Constanca Carvalho - University of LisbonMariana Vieira Crespo - Portuguese Soc Humane Educ, Lisbon, PortugalLusa Ferreira Bastos - Univ Porto, Inst Invest & Inovacao Saude, Oporto, PortugalAndrew Knight - University of WinchesterLuis Vicente - University of Lisbon
- Publication Details
- ALTEX, alternatives to animal experimentation, Vol.33(3), pp.243-249
- Publisher
- Springer Nature
- Number of pages
- 7
- Grant note
- UID/FIL/00678/2013 / Portuguese National Funds through CFCUL Unit funding
- Identifiers
- 991005694750507891
- Copyright
- © 2016 Carvalho et al.
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.136 Autism & Development Disorders
- 1.136.641 ADHD
- Web Of Science research areas
- Medicine, Research & Experimental
- ESI research areas
- Clinical Medicine