Contribution of different relapse phenotypes to disability in multiple sclerosis

T. Stewart; T. Spelman; E. Havrdova; D. Horakova; M. Trojano; G. Izquierdo; P. Duquette; M. Girard; A. Prat; A. Lugaresi; F. Grand’Maison; P. Grammond; P. Sola; V. Shaygannejad; R. Hupperts; R. Alroughani; C. Oreja-Guevara; E. Pucci; C. Boz; J. Lechner-Scott; R. Bergamaschi; V. van Pesch; G. Iuliano; C. Ramo; B. Taylor; M. Slee; D. Spitaleri; F. Granella; F. Verheul; P. McCombe; S. Hodgkinson; M.P. Amato; S. Vucic; O. Gray; E. Cristiano; M. Barnett; J.L. Sanchez Menoyo; E. van Munster; M.L. Saladino; J. Olascoaga; J. Prevost; N. Deri; C. Shaw; B. Singhal; F. Moore; C. Rózsa; N. Shuey; O. Skibina; I. Kister; T. Petkovska-Boskova; R. Ampapa; A. Kermode; H. Butzkueven; V. Jokubaitis; T. Kalincik

doi:10.1177/1352458516643392

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Contribution of different relapse phenotypes to disability in multiple sclerosis

Journal article

Peer reviewed

Contribution of different relapse phenotypes to disability in multiple sclerosis

T. Stewart, T. Spelman, E. Havrdova, D. Horakova, M. Trojano, G. Izquierdo, P. Duquette, M. Girard, A. Prat, A. Lugaresi, …

Multiple Sclerosis Journal, Vol.23(2), pp.266-276

2017

DOI: https://doi.org/10.1177/1352458516643392

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Abstract

Objective: This study evaluated the effect of relapse phenotype on disability accumulation in multiple sclerosis. Methods: Analysis of prospectively collected data was conducted in 19,504 patients with relapse-onset multiple sclerosis and minimum 1-year prospective follow-up from the MSBase cohort study. Multivariable linear regression models assessed associations between relapse incidence, phenotype and changes in disability (quantified with Expanded Disability Status Scale and its Functional System scores). Sensitivity analyses were conducted. Results: In 34,858 relapses recorded during 136,462 patient-years (median follow-up 5.9 years), higher relapse incidence was associated with greater disability accumulation (β = 0.16, p < 0.001). Relapses of all phenotypes promoted disability accumulation, with the most pronounced increase associated with pyramidal (β = 0.27 (0.25–0.29)), cerebellar (β = 0.35 (0.30–0.39)) and bowel/bladder (β = 0.42 (0.35–0.49)) phenotypes (mean (95% confidence interval)). Higher incidence of each relapse phenotype was associated with an increase in disability in the corresponding neurological domain, as well as anatomically related domains. Conclusion: Relapses are associated with accumulation of neurological disability. Relapses in pyramidal, cerebellar and bowel/bladder systems have the greatest association with disability change. Therefore, prevention of these relapses is an important objective of disease-modifying therapy. The differential impact of relapse phenotypes on disability outcomes could influence management of treatment failure in multiple sclerosis.

Details

Title: Contribution of different relapse phenotypes to disability in multiple sclerosis
Authors/Creators: T. Stewart (Author/Creator) - The University of Melbourne
T. Spelman (Author/Creator) - The University of Melbourne
E. Havrdova (Author/Creator) - Charles University
D. Horakova (Author/Creator) - Charles University
M. Trojano (Author/Creator) - University of Bari Aldo Moro
G. Izquierdo (Author/Creator)
P. Duquette (Author/Creator) - Université de Montréal
M. Girard (Author/Creator) - Université de Montréal
A. Prat (Author/Creator) - Université de Montréal
A. Lugaresi (Author/Creator)
F. Grand’Maison (Author/Creator)
P. Grammond (Author/Creator) - Université Laval
P. Sola (Author/Creator)
V. Shaygannejad (Author/Creator) - Isfahan University of Medical Sciences
R. Hupperts (Author/Creator)
R. Alroughani (Author/Creator) - Amiri Hospital
C. Oreja-Guevara (Author/Creator) - Universidad Complutense de Madrid
E. Pucci (Author/Creator)
C. Boz (Author/Creator) - Karadeniz Technical University
J. Lechner-Scott (Author/Creator)
R. Bergamaschi (Author/Creator)
V. van Pesch (Author/Creator) - UCLouvain
G. Iuliano (Author/Creator)
C. Ramo (Author/Creator) - Universitat Autònoma de Barcelona
B. Taylor (Author/Creator) - Menzies Research Institute
M. Slee (Author/Creator) - Flinders University
D. Spitaleri (Author/Creator)
F. Granella (Author/Creator) - University of Parma
F. Verheul (Author/Creator)
P. McCombe (Author/Creator) - The University of Queensland
S. Hodgkinson (Author/Creator) - UNSW Sydney
M.P. Amato (Author/Creator) - University of Florence
S. Vucic (Author/Creator) - Westmead Hospital
O. Gray (Author/Creator) - Craigavon Area Hospital
E. Cristiano (Author/Creator) - Hospital Italiano de Buenos Aires
M. Barnett (Author/Creator) - The University of Sydney
J.L. Sanchez Menoyo (Author/Creator)
E. van Munster (Author/Creator) - Robert Bosch (Germany)
M.L. Saladino (Author/Creator)
J. Olascoaga (Author/Creator)
J. Prevost (Author/Creator)
N. Deri (Author/Creator)
C. Shaw (Author/Creator) - Geelong Hospital
B. Singhal (Author/Creator) - Bombay Hospital
F. Moore (Author/Creator) - McGill University
C. Rózsa (Author/Creator)
N. Shuey (Author/Creator) - St Vincent's Health
O. Skibina (Author/Creator) - The Alfred Hospital
I. Kister (Author/Creator) - New York University
T. Petkovska-Boskova (Author/Creator)
R. Ampapa (Author/Creator)
A. Kermode (Author/Creator)
H. Butzkueven (Author/Creator) - Monash University
V. Jokubaitis (Author/Creator) - The University of Melbourne
T. Kalincik (Author/Creator) - The University of Melbourne
Publication Details: Multiple Sclerosis Journal, Vol.23(2), pp.266-276
Publisher: Sage Publications
Identifiers: 991005541160207891
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.203 Neuromuscular Disorders; 1.203.147 Multiple Sclerosis
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior