Journal article
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes
Nature Immunology, Vol.7(2), pp.173-178
2006
Abstract
Despite limited data supporting the superiority of dominant over subdominant responses, immunodominant epitopes represent the preferred vaccine candidates. To address the function of subdominant responses in human immunodeficiency virus infection, we analyzed cytotoxic T lymphocyte responses restricted by HLA-B*1503, a rare allele in a cohort infected with clade B, although common in one infected with clade C. HLA-B*1503 was associated with reduced viral loads in the clade B cohort but not the clade C cohort, although both shared the immunodominant response. Clade B viral control was associated with responses to several subdominant cytotoxic T lymphocyte epitopes, whereas their clade C variants were less well recognized. These data suggest that subdominant responses can contribute to in vivo viral control and that high HLA allele frequencies may drive the elimination of subdominant yet effective epitopes from circulating viral populations.
Details
- Title
- Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes
- Authors/Creators
- N. Frahm (Author/Creator) - Harvard Medical SchoolP. Kiepiela (Author/Creator) - University of KwaZulu-NatalS. Adams (Author/Creator) - National Institutes of Health Clinical CenterC.H. Linde (Author/Creator) - Harvard Medical SchoolH.S. Hewitt (Author/Creator) - Harvard Medical SchoolK. Sango (Author/Creator) - Harvard Medical SchoolM.E. Feeney (Author/Creator) - Harvard Medical SchoolM.M. Addo (Author/Creator) - Harvard Medical SchoolM. Lichterfeld (Author/Creator) - Harvard Medical SchoolM.P. Lahaie (Author/Creator) - Harvard Medical SchoolE. Pae (Author/Creator) - Fenway HealthA.G. Wurcel (Author/Creator) - Lemuel Shattuck HospitalT. Roach (Author/Creator) - Queen Elizabeth HospitalM.A. St John (Author/Creator)M. Altfeld (Author/Creator) - Harvard Medical SchoolF.M. Marincola (Author/Creator) - National Institutes of Health Clinical CenterC. Moore (Author/Creator) - Royal Perth HospitalS. Mallal (Author/Creator) - Royal Perth HospitalM. Carrington (Author/Creator) - Leidos (United States)D. Heckerman (Author/Creator) - Microsoft (Canada)T.M. Allen (Author/Creator) - Harvard Medical SchoolJ.I. Mullins (Author/Creator) - University of WashingtonB.T. Korber (Author/Creator) - Los Alamos National LaboratoryP.J.R. Goulder (Author/Creator) - University of OxfordB.D. Walker (Author/Creator) - Howard Hughes Medical InstituteC. Brander (Author/Creator) - Harvard Medical School
- Publication Details
- Nature Immunology, Vol.7(2), pp.173-178
- Publisher
- Nature Publishing Group
- Identifiers
- 991005540895107891
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.46 HIV Pathogenesis
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology