Copper-histidine ternary complex equilibria with glutamine, asparagine and serine. The implications for computer-simulated distributions of copper(II) in blood plasma

G. Berthon; B. Hacht; M-J Blais; P.M. May

doi:10.1016/S0020-1693(00)81215-3

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Copper-histidine ternary complex equilibria with glutamine, asparagine and serine. The implications for computer-simulated distributions of copper(II) in blood plasma

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Copper-histidine ternary complex equilibria with glutamine, asparagine and serine. The implications for computer-simulated distributions of copper(II) in blood plasma

G. Berthon, B. Hacht, M-J Blais and P.M. May

Inorganica Chimica Acta, Vol.125(4), pp.219-227

1986

DOI: https://doi.org/10.1016/S0020-1693(00)81215-3

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Abstract

The use of computer simulation techniques for assessing the percentage distribution of metal ions in biological fluids has recently been questioned on the grounds of observed discrepancies between such simulations and the results obtained experimentally by Neumann and Sass-Kortsak in their pioneering work on low-molecular-weight copper in reconstituted human serum. Recent work by our group has resolved the most serious of these discrepancies, but some worrying uncertainties remain regarding the ternary equilibria of copper(II) and histidine with glutamine, serine and asparagine. This paper describes an experimental investigation of these equilibria and the effect that the newly-determined data have on the computer-simulated distribution of copper(II) in blood plasma. Simulations have also been performed using the actual low-molecular-weight compositions of the biofluids studied by Neumann and Sass-Kortsak. The results show good agreement between calculated and experimentally observed distributions and confirm the usefulness of the simulation techniques.

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Title: Copper-histidine ternary complex equilibria with glutamine, asparagine and serine. The implications for computer-simulated distributions of copper(II) in blood plasma
Authors/Creators: G. Berthon (Author/Creator)
B. Hacht (Author/Creator)
M-J Blais (Author/Creator)
P.M. May (Author/Creator)
Publication Details: Inorganica Chimica Acta, Vol.125(4), pp.219-227
Publisher: Elsevier BV
Identifiers: 991005541738907891
Murdoch Affiliation: School of Chemical and Mathematical Science
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 2 Chemistry; 2.22 Inorganic & Nuclear Chemistry; 2.22.1278 Stability Constants
Web Of Science research areas: Chemistry, Inorganic & Nuclear
ESI research areas: Chemistry