Corneodesmosin DNA polymorphisms in MHC haplotypes and Japanese patients with psoriasis

J. Hui; A. Oka; G. Tamiya; M. Tomizawa; J.K. Kulski; W.J. Penhale; G.K. Tay; M. Iizuka; A. Ozawa; H. Inoko

doi:10.1034/j.1399-0039.2002.600110.x

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Corneodesmosin DNA polymorphisms in MHC haplotypes and Japanese patients with psoriasis

Journal article

Peer reviewed

Corneodesmosin DNA polymorphisms in MHC haplotypes and Japanese patients with psoriasis

J. Hui, A. Oka, G. Tamiya, M. Tomizawa, J.K. Kulski, W.J. Penhale, G.K. Tay, M. Iizuka, A. Ozawa and H. Inoko

Tissue Antigens, Vol.60(1), pp.77-83

2002

DOI: https://doi.org/10.1034/j.1399-0039.2002.600110.x

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Abstract

In order to examine the relationship between corneodesmosin (CDSN) and psoriasis we have determined the presence of CDSN polymorphisms by DNA sequencing in (a) nine B-LCL cell lines of major histocompatibility complex ancestral haplotypes known to be associated with psoriasis vulgaris including 13.1AH, 46.1AH, 46.2 and 57.1AH, and in (b) a group of 267 unrelated individuals comprising Japanese psoriasis patients (n = 101) and Japanese subjects without the disease (n = 166). Three novel CDSN gene sequences were identified. In addition, we have classified the 18 alleles into seven main groups based on phylogeny of non-synonymous substitutions. However, we have found no statistically significant differences between the patients and the unaffected individuals in any of these groups. These findings indicate that CDSN is not a major psoriasis susceptibility gene.

Details

Title: Corneodesmosin DNA polymorphisms in MHC haplotypes and Japanese patients with psoriasis
Authors/Creators: J. Hui (Author/Creator)
A. Oka (Author/Creator)
G. Tamiya (Author/Creator)
M. Tomizawa (Author/Creator)
J.K. Kulski (Author/Creator)
W.J. Penhale (Author/Creator)
G.K. Tay (Author/Creator)
M. Iizuka (Author/Creator)
A. Ozawa (Author/Creator)
H. Inoko (Author/Creator)
Publication Details: Tissue Antigens, Vol.60(1), pp.77-83
Publisher: Blackwell Publishing
Identifiers: 991005543332507891
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.106 Rheumatology; 1.106.737 Psoriasis
Web Of Science research areas: Cell Biology; Immunology; Pathology
ESI research areas: Molecular Biology & Genetics