Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change

W. H. Morgan; J. Khoo; A. Vukmirovic; A. Abdul-Rahman; D. An; A. Mehnert; D. Obreschkow; E. Chowdhury; D. Y. Yu

doi:10.1038/s41526-023-00269-0

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Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change

Journal article

Open access

Peer reviewed

Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change

W. H. Morgan, J. Khoo, A. Vukmirovic, A. Abdul-Rahman, D. An, A. Mehnert, D. Obreschkow, E. Chowdhury and D. Y. Yu

NPJ microgravity, Vol.9(1), Art. 28

2023

DOI: https://doi.org/10.1038/s41526-023-00269-0

PMID: 37002218

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Abstract

Physiology

Scientific data

Spaceflight associated neuro-ocular syndrome (SANS) is common amongst astronauts on long duration space missions and is associated with signs consistent with elevated cerebrospinal fluid (CSF) pressure. Additionally, CSF pressure has been found to be elevated in a significant proportion of astronauts in whom lumbar puncture was performed after successful mission completion. We have developed a retinal photoplethysmographic technique to measure retinal vein pulsation amplitudes. This technique has enabled the development of a non-invasive CSF pressure measurement apparatus. We tested the system on healthy volunteers in the sitting and supine posture to mimic the range of tilt table extremes and estimated the induced CSF pressure change using measurements from the CSF hydrostatic indifferent point. We found a significant relationship between pulsation amplitude change and estimated CSF pressure change (p < 0.0001) across a range from 2.7 to 7.1 mmHg. The increase in pulse amplitude was highest in the sitting posture with greater estimated CSF pressure increase (p < 0.0001), in keeping with physiologically predicted CSF pressure response. This technique may be useful for non-invasive measurement of CSF pressure fluctuations during long-term space voyages.

Details

Title: Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change
Authors/Creators: W. H. Morgan - Lions Eye Institute
J. Khoo - Lions Eye Institute
A. Vukmirovic - The University of Western Australia
A. Abdul-Rahman - Counties Manukau District Health Board
D. An - Lions Eye Institute
A. Mehnert - Lions Eye Institute
D. Obreschkow - International Centre for Radio Astronomy Research
E. Chowdhury - International Centre for Radio Astronomy Research
D. Y. Yu - Lions Eye Institute
Publication Details: NPJ microgravity, Vol.9(1), Art. 28
Publisher: Nature Publishing Group UK
Grant note: APP1162615; APP1162615; APP1162615; APP1162615; APP1162615; APP1162615; APP1162615; APP1162615; APP1162615 /
Identifiers: 991005568769807891
Murdoch Affiliation: School of Information Technology
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.255 Musculoskeletal Disorders; 1.255.1081 Microgravity Muscle Adaptation
Web Of Science research areas: Multidisciplinary Sciences
ESI research areas: Clinical Medicine