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CC BY-NC-ND V4.0, Open Access
Journal article
Cortico-cortical connectivity is influenced by levodopa in tremor-dominant Parkinson's disease
Neurobiology of disease, Vol.196, 106518
2024
PMID: 38679112
Abstract
Resting tremor is the most common presenting motor symptom in Parkinson's disease (PD). The supplementary motor area (SMA) is a main target of the basal-ganglia-thalamo-cortical circuit and has direct, facilitatory connections with the primary motor cortex (M1), which is important for the execution of voluntary movement. Dopamine potentially modulates SMA and M1 activity, and both regions have been implicated in resting tremor. This study investigated SMA-M1 connectivity in individuals with PD ON and OFF dopamine medication, and whether SMA-M1 connectivity is implicated in resting tremor. Dual-site transcranial magnetic stimulation was used to measure SMA-M1 connectivity in PD participants ON and OFF levodopa. Resting tremor was measured using electromyography and accelerometry. Stimulating SMA inhibited M1 excitability OFF levodopa, and facilitated M1 excitability ON levodopa. ON medication, SMA-M1 facilitation was significantly associated with smaller tremor than SMA-M1 inhibition. The current findings contribute to our understanding of the neural networks involved in PD which are altered by levodopa medication and provide a neurophysiological basis for the development of interventions to treat resting tremor.
Details
- Title
- Cortico-cortical connectivity is influenced by levodopa in tremor-dominant Parkinson's disease
- Authors/Creators
- B K Rurak - Murdoch UniversityJ TanJ P Rodrigues - Hollywood Private HospitalB D Power - The University of Notre Dame AustraliaP D Drummond - Murdoch University, Centre for Healthy AgeingA M Vallence - Murdoch University, Centre for Healthy Ageing
- Publication Details
- Neurobiology of disease, Vol.196, 106518
- Publisher
- Elsevier Inc.
- Identifiers
- 991005659468407891
- Copyright
- © 2024 Published by Elsevier Inc.
- Murdoch Affiliation
- Centre for Healthy Ageing; School of Psychology
- Language
- English
- Resource Type
- Journal article
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