Journal article
Cost-effectiveness of colorectal cancer screening: Comparison of community-based flexible sigmoidoscopy with fecal occult blood testing and colonoscopy
Journal of Gastroenterology and Hepatology, Vol.19(1), pp.38-47
2004
Abstract
Background and Aims: To determine the cost-effectiveness of screening for colorectal cancer using flexible sigmoidoscopy once every 10 years, compared with annual and biennial rehydrated Hemoccult fecal occult blood testing and colonoscopy once every 10 years, or no screening.
Methods: A Markov model was developed in order to simulate the progression of a cohort of asymptomatic, average-risk individuals aged 55–64 years who were moving through a defined series of states towards death. The main outcome measures were: cases of colorectal cancer averted, colorectal cancer deaths averted, and cost per life-year saved.
Results: Colonoscopy averted the greatest number of cases of colorectal cancer (35%), followed by flexible sigmoidoscopy (25%), and annual (24%) and biennial (14%) fecal occult blood testing. Colonoscopy averted the greatest number of deaths from colorectal cancer (31%), followed by annual fecal occult blood testing (29%), flexible sigmoidoscopy (21%) and biennial fecal occult blood testing (19%). Flexible sigmoidoscopy was the most efficient in terms of cost per life-year saved (A$16 801), followed by colonoscopy (A$19 285), biennial (A$41 183), and annual (A$46 900) fecal occult blood testing.
Conclusions: Flexible sigmoidoscopy and colonoscopy are cost-effective strategies for reducing the disease burden of colorectal cancer.
Details
- Title
- Cost-effectiveness of colorectal cancer screening: Comparison of community-based flexible sigmoidoscopy with fecal occult blood testing and colonoscopy
- Authors/Creators
- B.A. O'Leary (Author/Creator) - The Lewin Group, a Division of Quintiles Australia, Sydney, New South Wales, Australia.J.K. Olynyk (Author/Creator) - Fremantle HospitalA.M. Neville (Author/Creator) - The Lewin Group, a Division of Quintiles Australia, Sydney, New South Wales,C.F. Platell (Author/Creator) - Fremantle Hospital
- Publication Details
- Journal of Gastroenterology and Hepatology, Vol.19(1), pp.38-47
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005542241107891
- Copyright
- © 2004 Blackwell Publishing Asia Pty Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.111 Liver & Colon Cancer
- 1.111.551 Colonoscopy
- Web Of Science research areas
- Gastroenterology & Hepatology
- ESI research areas
- Clinical Medicine