Could a loss of memory T cells limit responses to hepatitis C virus (HCV) antigens in blood leucocytes from patients chronically infected with HCV before and during pegylated interferon-α and ribavirin therapy?

S. Lee; T. Hammond; M.W. Watson; J.P. Flexman; W. Cheng; S. Fernandez; P. Price

doi:10.1111/j.1365-2249.2010.04141.x

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Could a loss of memory T cells limit responses to hepatitis C virus (HCV) antigens in blood leucocytes from patients chronically infected with HCV before and during pegylated interferon-α and ribavirin therapy?

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Could a loss of memory T cells limit responses to hepatitis C virus (HCV) antigens in blood leucocytes from patients chronically infected with HCV before and during pegylated interferon-α and ribavirin therapy?

S. Lee, T. Hammond, M.W. Watson, J.P. Flexman, W. Cheng, S. Fernandez and P. Price

Clinical & Experimental Immunology, Vol.161(1), pp.118-126

2010

DOI: https://doi.org/10.1111/j.1365-2249.2010.04141.x

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Abstract

The proportions and activation status of T cells may influence responses to hepatitis C virus (HCV) and treatment outcome in patients receiving pegylated interferon (IFN)-α/ribavirin therapy. We confirmed that IFN-γ enzyme-linked immunospot (ELISPOT) responses to HCV are poor in HCV patients and showed that responses to HCV and cytomegalovirus (CMV) antigens decrease during therapy. This was most apparent in patients with sustained virological response (SVR). Baseline frequencies of CD4+ effector memory (TEM) T cells were lower in SVR than non-SVR. Proportions of CD4+ and CD8+ TEM and terminally differentiated effector memory (TEMRA) T cells declined on therapy in SVR, as did proportions of Fas+ CD8+ TEMRA T cells. Baseline frequencies of programmed death (PD)-1-expressing CD4+ TEM and TEMRA T-cells were higher in SVR. Therapy increased percentages of PD-1+ CD4+ central memory (TCM) T cells and PD-1+ CD8+ TEM and TEMRA T cells in SVR. We conclude that successful therapy depletes circulating antigen-specific CD4+ T cell responses. This paralleled decreases in proportions of effector memory T cells and higher percentages of CD4+ TCM T cells expressing PD-1.

Details

Title: Could a loss of memory T cells limit responses to hepatitis C virus (HCV) antigens in blood leucocytes from patients chronically infected with HCV before and during pegylated interferon-α and ribavirin therapy?
Authors/Creators: S. Lee (Author/Creator) - The University of Western Australia
T. Hammond (Author/Creator) - The University of Western Australia
M.W. Watson (Author/Creator) - Centre for Cellular and Molecular Biology
J.P. Flexman (Author/Creator) - Department of Microbiology and Infectious Disease,
W. Cheng (Author/Creator) - Department of Gastroenterology and Hepatology, and
S. Fernandez (Author/Creator) - The University of Western Australia
P. Price (Author/Creator) - Royal Perth Hospital
Publication Details: Clinical & Experimental Immunology, Vol.161(1), pp.118-126
Publisher: Wiley
Identifiers: 991005541728607891
Copyright: © 2010 British Society for Immunology
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.125 Hepatitis; 1.125.83 HCV
Web Of Science research areas: Immunology
ESI research areas: Immunology