Coxsackie virus-like particles in skeletal muscle from a case of polymyositis

F.L. Mastaglia; J.N. Walton

doi:10.1016/0022-510X(70)90109-7

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Coxsackie virus-like particles in skeletal muscle from a case of polymyositis

Journal article

Peer reviewed

Coxsackie virus-like particles in skeletal muscle from a case of polymyositis

F.L. Mastaglia and J.N. Walton

Journal of the Neurological Sciences, Vol.11(6), pp.593-599

1970

DOI: https://doi.org/10.1016/0022-510X(70)90109-7

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Abstract

Electron microscopic examination of biopsied skeletal muscle from a young woman with subacute polymyositis revealed cytoplasmic inclusions composed of 160–240 Å particles which closely resembled picorna virions. These were found only in regenerating muscle fibres and were associated with other cytoplasmic and nuclear changes. This finding emphasizes the importance of subjecting muscle from cases of polymyositis to electron microscopic examination and provides a possible mechanism whereby the antigenic properties of skeletal muscle may be altered so as to render it susceptible to normal immune mechanisms.

Details

Title: Coxsackie virus-like particles in skeletal muscle from a case of polymyositis
Authors/Creators: F.L. Mastaglia (Author/Creator) - Muscular Dystrophy Research Laboratories, Regional Neurological Centre, General Hospital, Newcastle upon Tyne Great Britain
J.N. Walton (Author/Creator) - Muscular Dystrophy Research Laboratories, Regional Neurological Centre, General Hospital, Newcastle upon Tyne Great Britain
Publication Details: Journal of the Neurological Sciences, Vol.11(6), pp.593-599
Publisher: Elsevier BV
Identifiers: 991005542322807891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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