Journal article
Cross-regulation of JAK and Src kinases
Growth Factors, Vol.24(1), pp.89-95
2006
Abstract
Members of the Janus kinase (JAK) family, JAK1, JAK2, JAK3 and Tyk2 are intimately involved in the signalling events initiated by cytokines activating cell surface receptors. They are responsible for phosphorylating these receptors, which create docking sites for downstream molecules such as the signal transducer and activator of transcription family members. In addition, cytokine receptors associate with members of the Src family kinase (SFK). JAKs and SFK work in concert to activate many of the signalling molecules, with both kinase families required for optimal transmission of intracellular signals. JAKs and SFK are also required for the activation and recruitment of negative regulators of cytokine signalling, e.g., protein tyrosine phosphatases (PTPs) and suppressors of cytokine signalling. Aberrant activity of the JAK-Src kinase duet can result in hemopoietic abnormalities including leukaemia. Additionally, the recent identification of a somatic JAK2 mutation as the cause of polycythema vera, further highlights the clinical importance of these molecules.
Details
- Title
- Cross-regulation of JAK and Src kinases
- Authors/Creators
- E. Ingley (Author/Creator) - The University of Western AustraliaS.P. Klinken (Author/Creator) - UWA Centre for Medical Research
- Publication Details
- Growth Factors, Vol.24(1), pp.89-95
- Publisher
- Taylor & Francis
- Identifiers
- 991005541454907891
- Copyright
- © 2006 Taylor & Francis.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.1264 STAT3 Signaling
- Web Of Science research areas
- Cell Biology
- Endocrinology & Metabolism
- ESI research areas
- Molecular Biology & Genetics