Cryptosporidium hominis n. sp. (Apicomplexa: Cryptosporidiidae) from Homo sapiens

U.M. Morgan-Ryan; A. Fall; L.A. Ward; N. Hijjawi; I. Sulaiman; R. Payer; R.C.A. Thompson; M.E. Olson; A.A. Lal; L. Xiao

doi:10.1111/j.1550-7408.2002.tb00224.x

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Cryptosporidium hominis n. sp. (Apicomplexa: Cryptosporidiidae) from Homo sapiens

Journal article

Peer reviewed

Cryptosporidium hominis n. sp. (Apicomplexa: Cryptosporidiidae) from Homo sapiens

U.M. Morgan-Ryan, A. Fall, L.A. Ward, N. Hijjawi, I. Sulaiman, R. Payer, R.C.A. Thompson, M.E. Olson, A.A. Lal and L. Xiao

The Journal of Eukaryotic Microbiology, Vol.49(6), pp.433-440

11/2002

DOI: https://doi.org/10.1111/j.1550-7408.2002.tb00224.x

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Abstract

The structure and infectivity of the oocysts of a new species of Cryptosporidium from the feces of humans are described. Oocysts are structurally indistinguishable from those of Cryptosporidium parvum. Oocysts of the new species are passed fully sporulated, lack sporocysts, and measure 4.4-5.4 μm (mean = 4.86) × 4.4-5.9 μm (mean = 5.2 μm) with a length to width ratio 1.0-1.09 (mean 1.07) (n = 100). Oocysts were not infectious for ARC Swiss mice, nude mice, Wistar rat pups, puppies, kittens or calves, but were infectious to neonatal gnotobiotic pigs. Pathogenicity studies in the gnotobiotic pig model revealed significant differences in parasite-associated lesion distribution (P = 0.005 to P = 0.02) and intensity of infection (P = 0.04) between C. parvum and this newly described species from humans. In vitro cultivation studies have also revealed growth differences between the two species. Multi-locus analysis of numerous unlinked loci, including a preliminary sequence scan of the entire genome demonstrated this species to be distinct from C. parvum and also demonstrated a lack of recombination, providing further support for its species status. Based on biological and molecular data, this Cryptosporidium infecting the intestine of humans is proposed to be a new species Cryptosporidium hominis n. sp.

Details

Title: Cryptosporidium hominis n. sp. (Apicomplexa: Cryptosporidiidae) from Homo sapiens
Authors/Creators: U.M. Morgan-Ryan (Author/Creator) - Murdoch University
A. Fall (Author/Creator) - Murdoch University
L.A. Ward (Author/Creator) - bFood Animal Health Research Program and Department of Veterinary Preventative Medicine, Ohio Agricu
N. Hijjawi (Author/Creator) - Murdoch University
I. Sulaiman (Author/Creator) - National Center for Infectious Diseases
R. Payer (Author/Creator)
R.C.A. Thompson (Author/Creator) - Murdoch University
M.E. Olson (Author/Creator) - University of Calgary
A.A. Lal (Author/Creator) - National Center for Infectious Diseases
L. Xiao (Author/Creator) - National Center for Infectious Diseases
Publication Details: The Journal of Eukaryotic Microbiology, Vol.49(6), pp.433-440
Publisher: Blackwell Publishing
Identifiers: 991005544324107891
Copyright: © 2002 by the Society of Protozoologists
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.246 Diarrheal Diseases; 1.246.985 Cryptosporidium
Web Of Science research areas: Microbiology
ESI research areas: Microbiology