Journal article
Cw * 1701 defines a divergent African HLA-C allelic lineage
Immunogenetics, Vol.46(3), pp.173-180
1997
Abstract
The complete sequence of a new HLA-C allele, Cw * 1701, was determined from a South African Zulu individual. Unique features that distinguish Cw * 1701 from other HLA-C alleles include multiple point substitutions and an 18 nucleotide insertion in exon 5, which encodes the transmembrane domain. In a phylogenetic analysis of HLA-C sequences, Cw * 1701 forms a third, distinct allelic lineage. A comparison of the transmembrane domain of Cw * 1701 with other HLA-B and -C alleles reveals that duplications and deletions have been common in the evolution of these loci. A polymerase chain reaction based typing method was used to determine the distribution of this unusual allele in human populations. In contrast to the other two lineages of HLA-C alleles, the Cw * 17 lineage is found at high frequencies only in populations of African descent. In addition, the HLA-B/Cw * 17 haplotype diversity is higher in Africa.
Details
- Title
- Cw * 1701 defines a divergent African HLA-C allelic lineage
- Authors/Creators
- R.S. Wells (Author/Creator)M.T. Seielstad (Author/Creator)M. Bunce (Author/Creator)D.B. Tyan (Author/Creator)E. Bekele (Author/Creator)P. Parham (Author/Creator)
- Publication Details
- Immunogenetics, Vol.46(3), pp.173-180
- Publisher
- Springer-Verlag
- Identifiers
- 991005540700107891
- Copyright
- 1997 Springer-Verlag
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
28 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.607 MHC Diversity
- Web Of Science research areas
- Genetics & Heredity
- Immunology
- ESI research areas
- Immunology