Journal article
Cysteinyl-leukotriene receptor antagonism blunts the acute hypotensive response to endotoxin in cats
Journal of Feline Medicine and Surgery, Vol.12(10), pp.754-759
2010
Abstract
This study evaluated the effects of a cysteinyl-leukotriene-1 (cys-LT-1) receptor antagonist, zarfirlukast, during feline endotoxemia. Six adult, sexually intact male cats received either placebo or zarfirlukast (10 mg, PO) and endotoxin (2 μg/kg/h q 6 h) in a cross-over design. Rectal temperature, heart rate, systolic arterial blood pressure, plasma tumor necrosis factor (TNF) activity, interleukin (IL)-6 concentration and urine cys-LT to creatinine ratio were evaluated. The rectal temperature, plasma TNF activity and IL-6 concentrations were significantly higher and systolic arterial blood pressure and heart rate significantly lower after endotoxin infusion. Cats treated with zafirlukast had a significantly higher blood pressure at 4 h (P=0.002) compared to placebo. Urine cys-LT to creatinine ratio was significantly greater in the cats treated with zafirlukast compared to placebo (P=0.02). Zafirlukast administration ameliorated the acute hypotensive response to endotoxin in cats, but failed to significantly alter rectal temperature, heart rate or production of TNF and IL-6.
Details
- Title
- Cysteinyl-leukotriene receptor antagonism blunts the acute hypotensive response to endotoxin in cats
- Authors/Creators
- A.E. DeClue (Author/Creator)C.R. Sharp (Author/Creator)R.L. Cohen (Author/Creator)E.F. Leverenz (Author/Creator)C.R. Reinero (Author/Creator)
- Publication Details
- Journal of Feline Medicine and Surgery, Vol.12(10), pp.754-759
- Publisher
- Elsevier Ltd.
- Identifiers
- 991005540534907891
- Copyright
- © 2010 ISFM and AAFP
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.181 Molecular Toxicology
- 1.181.389 Lipoxygenase Pathways
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science