Cytokine expression in murine cytomegalovirus-induced myocarditis: modulation with interferon-α therapy

J.C. Lenzo; J.P. Mansfield; S. Sivamoorthy; V.S. Cull; C.M. James

doi:10.1016/S0008-8749(03)00150-3

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Cytokine expression in murine cytomegalovirus-induced myocarditis: modulation with interferon-α therapy

Journal article

Peer reviewed

Cytokine expression in murine cytomegalovirus-induced myocarditis: modulation with interferon-α therapy

J.C. Lenzo, J.P. Mansfield, S. Sivamoorthy, V.S. Cull and C.M. James

Cellular Immunology, Vol.223(1), pp.77-86

2003

DOI: https://doi.org/10.1016/S0008-8749(03)00150-3

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Abstract

Cytomegalovirus-induced myocarditis is largely immune-mediated. BALB/c mice produced higher levels of IL-4 in the heart indicative of a Th2-like response. Although IL-6, IL-10, IL-18, and TNF-α were produced in the heart during acute infection, BALB/c mice lacked a substantial IL-2 and IFN-γ response. Conversely, C57BL/6 mice produced significant levels of IFN-γ in the heart with no significant levels of IL-4 or IL-6, suggestive of a dominant Th1-like response to virus infection. IFN-α/β immunotherapy is known to suppress the development of MCMV-myocarditis. Cytokine secretion in IFN-stimulated MCMV-infected BALB/c myocytes was found to be IFN subtype-dependent with elevation of IL-6 and IL-18 levels. During the chronic phase of disease, IFNA6 DNA treatment in vivo increased IL-18 production in the heart. These results suggest that IFN subtype therapy may have immunomodulating effects in reducing disease severity in BALB/c mice via regulation of cytokine production in the heart.

Details

Title: Cytokine expression in murine cytomegalovirus-induced myocarditis: modulation with interferon-α therapy
Authors/Creators: J.C. Lenzo (Author/Creator) - Murdoch University
J.P. Mansfield (Author/Creator) - Murdoch University
S. Sivamoorthy (Author/Creator) - Murdoch University
V.S. Cull (Author/Creator) - Murdoch University
C.M. James (Author/Creator) - Murdoch University
Publication Details: Cellular Immunology, Vol.223(1), pp.77-86
Publisher: Academic Press Inc.
Identifiers: 991005542468407891
Copyright: 2003 Elsevier Science
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.37 Cardiology - General; 1.37.1920 Myocarditis
Web Of Science research areas: Cell Biology; Immunology
ESI research areas: Immunology