Cytoplasmic binding of dexamethasone and induction of tyrosine aminotransferase in neonatal rat liver

M.H. Cake; A.V. Ghisalberti; I.T. Oliver

doi:10.1016/0006-291X(73)90791-2

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Cytoplasmic binding of dexamethasone and induction of tyrosine aminotransferase in neonatal rat liver

Journal article

Peer reviewed

Cytoplasmic binding of dexamethasone and induction of tyrosine aminotransferase in neonatal rat liver

M.H. Cake, A.V. Ghisalberti and I.T. Oliver

Biochemical and Biophysical Research Communications, Vol.54(3), pp.983-990

1973

DOI: https://doi.org/10.1016/0006-291X(73)90791-2

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Abstract

Dexamethasone administration markedly increases the activity of tyrosine aminotransferase in postnatal rat liver. The glucocorticoid fails to induce the enzyme in foetal rats when administered in utero. Dexamethasone binding activity of rat liver cytoplasm is low or absent in foetal animals but increases to adult levels 1–2 days after birth. In vitro experiments with isolated nuclei indicate that foetal nuclei have the capacity to accumulate dexamethasone but only when presented with cytosol-bound glucocorticoid.

Details

Title: Cytoplasmic binding of dexamethasone and induction of tyrosine aminotransferase in neonatal rat liver
Authors/Creators: M.H. Cake (Author/Creator) - The University of Western Australia
A.V. Ghisalberti (Author/Creator) - The University of Western Australia
I.T. Oliver (Author/Creator) - The University of Western Australia
Publication Details: Biochemical and Biophysical Research Communications, Vol.54(3), pp.983-990
Publisher: Academic Press
Identifiers: 991005544276207891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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