Journal article
D-penicillamine-associated myasthenia gravis: Immunological and electrophysiological studies
Muscle & Nerve, Vol.5(4), pp.328-334
1982
Abstract
Immunological and electrophysiological features were investigated in a patient with rheumatoid arthritis who developed myasthenic symptoms after 10 months of treatment with D-penicillamine (D-pen). After an initial rise, acetylcholine receptor (AChR) antibodies gradually fell from 24.4 nmole α-bungarotoxin bound/liter to 1.8 nmole/liter following withdrawal of the drug, and this was associated with clinical and electrophysiological improvement. Immunoglobulin synthesis by peripheral blood lymphocytes cultured with pokeweed mitogen and D-pen was significantly increased at D-pen concentrations of 10–100 μg/ml in 2 patients with D-pen associated myasthenia gravis and 1 out of 3 normal individuals. Furthermore, lymphocytes from 1 myasthenic patient synthesized detactable AChR antibodies in vitro, and the amount of receptor antibody produced was increased in the presence of the drug. This effect was most marked at a concentration of 10 μg/ml which is thought to approximate the concentration in vivo. Our results confirm the in vivo findings of others that D-pen may have different effects on immunoglobulin production in different individuals and may also enhance the synthesis of at least 1 autoantibody, the AChR antibody.
Details
- Title
- D-penicillamine-associated myasthenia gravis: Immunological and electrophysiological studies
- Authors/Creators
- P.R.W. Fawcett (Author/Creator)S.M. McLachlan (Author/Creator)L.V.B. Nicholson (Author/Creator)Z. Argov (Author/Creator)F.L. Mastaglia (Author/Creator)
- Publication Details
- Muscle & Nerve, Vol.5(4), pp.328-334
- Publisher
- John Wiley and Sons Inc.
- Identifiers
- 991005542505607891
- Copyright
- © 1982 John Wiley & Sons, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
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- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.1325 Thymectomy in Myasthenia
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior