Daily variation of macronutrient concentrations in mature human milk over 3 weeks

G.E. Leghi; C.T. Lai; A. Narayanan; M.J. Netting; M. Dymock; A. Rea; M.E. Wlodek; D.T. Geddes; B.S. Muhlhausler

doi:10.1038/s41598-021-89460-5

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Daily variation of macronutrient concentrations in mature human milk over 3 weeks

Journal article

Open access

Peer reviewed

Daily variation of macronutrient concentrations in mature human milk over 3 weeks

G.E. Leghi, C.T. Lai, A. Narayanan, M.J. Netting, M. Dymock, A. Rea, M.E. Wlodek, D.T. Geddes and B.S. Muhlhausler

Scientific Reports, Vol.11(1), Art. 10224

2021

DOI: https://doi.org/10.1038/s41598-021-89460-5

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Abstract

Human milk (HM) composition is known to be highly variable, both between individuals and across the duration of lactation. It is less clear, however, to what extent fat, lactose and protein concentrations in HM change daily over shorter time periods in mature HM, and no studies have evaluated this to date. The aim of this study was to systematically assess and compare HM macronutrient concentrations in samples collected at different times of day, from left and right breasts and daily across a 3-week period in the same woman. Fifteen lactating women (1.6–4.9 months postpartum) collected daily pre-feed HM samples from both breasts each morning for 21 consecutive days and completed intensive sampling once a week (morning, afternoon and evening samples) during this period. Concentrations of fat, protein and lactose in HM did not differ according to time of day, day of week or breast used for collection. The results of this study suggest that pre-feed samples collected at any point across a 3-week period and from either the left or right breast provide comparable measures of fat, protein and lactose concentrations in mature HM, in pragmatic studies where women are collecting their own HM samples.

Details

Title: Daily variation of macronutrient concentrations in mature human milk over 3 weeks
Authors/Creators: G.E. Leghi (Author/Creator) - The University of Adelaide
C.T. Lai (Author/Creator) - The University of Western Australia
A. Narayanan (Author/Creator) - The University of Western Australia
M.J. Netting (Author/Creator) - South Australian Health and Medical Research Institute
M. Dymock (Author/Creator) - The University of Western Australia
A. Rea (Author/Creator) - Murdoch University
M.E. Wlodek (Author/Creator) - The University of Melbourne
D.T. Geddes (Author/Creator) - The University of Western Australia
B.S. Muhlhausler (Author/Creator) - Commonwealth Scientific and Industrial Research Organisation
Publication Details: Scientific Reports, Vol.11(1), Art. 10224
Publisher: Springer Nature
Identifiers: 991005542117007891
Copyright: © 2021 Springer Nature Limited
Murdoch Affiliation: School of Mathematics, Statistics, Chemistry and Physics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.72 Obstetrics & Gynecology; 1.72.891 Breastfeeding
Web Of Science research areas: Nutrition & Dietetics
ESI research areas: Clinical Medicine