Journal article
Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies
Clinical chemistry (Baltimore, Md.), Vol.64(1), pp.183-191
2018
PMCID: PMC5837824
PMID: 29187356
Abstract
Background
Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined.
Methods
We performed Mendelian randomization (MR) analysis using an established dairy intake-associated genetic polymorphism located upstream of the lactase gene (LCT-13910 C/T, rs4988235) as an instrumental variable (IV). Linear regression models were fitted to analyze associations between (a) dairy intake and BMI, (b) rs4988235 and dairy intake, and (c) rs4988235 and BMI in each study. The causal effect of dairy intake on BMI was quantified by IV estimators among 184802 participants from 25 studies.
Result
Higher dairy intake was associated with higher BMI (β = 0.03 kg/m2 per serving/day; 95% CI, 0.00–0.06; P = 0.04), whereas the LCT genotype with 1 or 2 T allele was significantly associated with 0.20 (95% CI, 0.14–0.25) serving/day higher dairy intake (P = 3.15 × 10−12) and 0.12 (95% CI, 0.06–0.17) kg/m2 higher BMI (P = 2.11 × 10−5). MR analysis showed that the genetically determined higher dairy intake was significantly associated with higher BMI (β = 0.60 kg/m2 per serving/day; 95% CI, 0.27–0.92; P = 3.0 × 10−4).
Conclusion
The present study provides strong evidence to support a causal effect of higher dairy intake on increased BMI among adults.
Details
- Title
- Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies
- Authors/Creators
- Tao Huang - Peking UniversityMing Ding - Supreme Council Of HealthHelle K. M. Bergholdt - Naestved Hosp, Dept Clin Biochem, Naestved, DenmarkTiange Wang - Tulane UniversityYoriko Heianza - Tulane UniversityDian-jianyi Sun - Tulane UniversityAlexis C. Frazier-WoodStella Aslibekyan - University of AlabamaKari E. North - Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USATrudy Voortman - Univ Med Ctr, Dept Epidemiol, Erasmus MC, Rotterdam, NetherlandsMariaelisa Graff - Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USACaren E. Smith - Tufts UniversityChao-Qiang Lai - Tufts UniversityAnette Varbo - University of CopenhagenRozenn N. Lemaitre - University of WashingtonM. Ester A. L. de Jonge - Univ Med Ctr, Dept Epidemiol, Erasmus MC, Rotterdam, NetherlandsFredric Fumeron - InsermDolores Corella - Universitat de ValènciaCarol A. Wang - Univ Western Australia, Sch Womens & Infants Hlth, Crawley, WA, AustraliaAnne Tjonneland - Danish Canc Soc, Res Ctr, Copenhagen, DenmarkKim Overvad - Aarhus Univ, Epidemiol Sect, Dept Publ Hlth, Aarhus, DenmarkThorkild I. A. Sorensen - University of CopenhagenMary F. Feitosa - Supreme Council Of HealthMary K. Wojczynski - Supreme Council Of HealthMika Kahonen - Tampere UniversityFrida Renstrom - Lund UniversityBruce M. Psaty - Kaiser (Czechia)David S. Siscovick - College Station Medical CenterInes Barroso - Addenbrookes Hosp, Inst Metab Sci, NIHR Cambridge Biomed Res Ctr, Cambridge, EnglandIngegerd Johansson - Umeå UniversityDena Hernandez - NIA, Neurogenet Lab, Bethesda, MD 20892 USALuigi Ferrucci - NIA, Translat Gerontol Branch, Baltimore, MD 21224 USAStefania Bandinelli - Florence (Netherlands)Allan Linneberg - Res Ctr Prevent & Hlth, Copenhagen, DenmarkM. Carola Zillikens - Univ Med Ctr, Erasmus MC, Dept Internal Med, Rotterdam, NetherlandsCamilla Helene Sandholt - University of CopenhagenOluf Pedersen - University of CopenhagenTorben Hansen - University of CopenhagenChristina-Alexandra Schulz - Lund UniversityEmily Sonestedt - Lund UniversityMarju Orho-Melander - Lund UniversityTzu-An ChenJerome I. Rotter - Biomed Research InstituteMathew A. Allison - College Station Medical CenterStephen S. Rich - University of VirginiaJose V. Sorli - Universitat de ValènciaOscar Coltell - Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, SpainCraig E. Pennell - Univ Western Australia, Sch Womens & Infants Hlth, Crawley, WA, AustraliaPeter Eastwood - Univ Western Australia, Sch Anat Physiol & Human Biol, Nedlands, WA, AustraliaAlbert Hofman - Tulane UniversityAndre G. Uitterlinden - Univ Med Ctr, Erasmus MC, Dept Internal Med, Rotterdam, NetherlandsFrank J. A. van Rooij - Univ Med Ctr, Dept Epidemiol, Erasmus MC, Rotterdam, NetherlandsAudrey Y. Chu - Brigham and Women's HospitalLynda M. Rose - Brigham and Women's HospitalPaul M. Ridker - Brigham and Women's HospitalJorma Viikari - University of TurkuOlli Raitakari - College Station Medical CenterTerho Lehtimaki - Fimlab (Finland)Vera Mikkila - University of TurkuWalter C. Willett - Supreme Council Of HealthYujie Wang - Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USAKatherine L. Tucker - Univ Massachusetts, Ctr Populat Hlth, Biomed & Nutr Sci, Lowell, MA USAJose M. Ordovas - Tufts UniversityTuomas O. Kilpelainen - University of CopenhagenMichael A. Province - Supreme Council Of HealthPaul W. Franks - Supreme Council Of HealthDonna K. Arnett - University of KentuckyToshiko Tanaka - NIA, Translat Gerontol Branch, Baltimore, MD 21224 USAUlla Toft - Res Ctr Prevent & Hlth, Copenhagen, DenmarkUlrika Ericson - Lund UniversityOscar H. Franco - Univ Med Ctr, Dept Epidemiol, Erasmus MC, Rotterdam, NetherlandsDariush Mozaffarian - Tufts UniversityFrank B. Hu - Supreme Council Of HealthDaniel I. Chasman - Brigham and Women's HospitalBorge G. Nordestgaard - University of CopenhagenChristina Ellervik - University of CopenhagenLu Qi - Tulane UniversityMendelian Randomization Dairy Cons
- Publication Details
- Clinical chemistry (Baltimore, Md.), Vol.64(1), pp.183-191
- Publisher
- Oxford Univ Press
- Number of pages
- 9
- Grant note
- Vasterbotten Intervention Project Real Colegio Complutense at Harvard University Northern Sweden Diet Database UWA Faculty of Medicine, Dentistry and Health Sciences Hansen Group; Pedersen Group / NNF Center for Basic Metabolic Research; Novo Nordisk Foundation University of Western Australia (UWA) Edith Cowan University Swedish Research Council; Swedish Research Council for Health Working Life & Welfare (Forte); Swedish Research Council Formas Curtin University NNF14OC0011039 / Novo Nordisk Fonden; Novo Nordisk Foundation Women's and Infants' Research Foundation (King Edward Memorial Hospital) Telethon Kids Institute NHMRC; National Health and Medical Research Council (NHMRC) of Australia Raine Medical Research Foundation
- Identifiers
- 991005592765607891
- Copyright
- © 2017 American Association for Clinical Chemistry
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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