Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study

C. Domenighetti; P‐E Sugier; A. Ashok Kumar Sreelatha; C. Schulte; S. Grover; O. Mohamed; B. Portugal; P. May; D.R. Bobbili; M. Radivojkov‐Blagojevic; P. Lichtner; A.B. Singleton; D.G. Hernandez; C. Edsall; G.D. Mellick; A. Zimprich; W. Pirker; E. Rogaeva; A.E. Lang; S. Kõks; P. Taba; S. Lesage; A. Brice; J‐C Corvol; M‐C Chartier‐Harlin; E. Mutez; K. Brockmann; A.B. Deutschländer; G.M. Hadjigeorgiou; E. Dardiotis; L. Stefanis; A.M. Simitsi; E.M. Valente; S. Petrucci; S. Duga; L. Straniero; A. Zecchinelli; G. Pezzoli; L. Brighina; C. Ferrarese; G. Annesi; A. Quattrone; M. Gagliardi; H. Matsuo; Y. Kawamura; N. Hattori; K. Nishioka; S.J. Chung; Y.J. Kim; P. Kolber; B.P.C. Warrenburg; B.R. Bloem; J. Aasly; M. Toft; L. Pihlstrøm; L. Correia Guedes; J.J. Ferreira; S. Bardien; J. Carr; E. Tolosa; M. Ezquerra; P. Pastor; M. Diez‐Fairen; K. Wirdefeldt; N.L. Pedersen; C. Ran; A.C. Belin; A. Puschmann; C. Hellberg; C.E. Clarke; K.E. Morrison; M. Tan; D. Krainc; L.F. Burbulla; M.J. Farrer; R. Krüger; T. Gasser; M. Sharma; A. Elbaz

doi:10.1002/mds.28902

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Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study

Journal article

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Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study

C. Domenighetti, P‐E Sugier, A. Ashok Kumar Sreelatha, C. Schulte, S. Grover, O. Mohamed, B. Portugal, P. May, D.R. Bobbili, M. Radivojkov‐Blagojevic, …

Movement Disorders, Vol.37(4), pp.857-864

2022

DOI: https://doi.org/10.1002/mds.28902

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Abstract

Background Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding. Objective The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR). Methods We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry). Results Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12–2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37–4.56], P = 0.003; P-difference with women = 0.029). Conclusions Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society

Details

Title: Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study
Authors/Creators: C. Domenighetti (Author/Creator)
P‐E Sugier (Author/Creator)
A. Ashok Kumar Sreelatha (Author/Creator)
C. Schulte (Author/Creator)
S. Grover (Author/Creator)
O. Mohamed (Author/Creator)
B. Portugal (Author/Creator)
P. May (Author/Creator)
D.R. Bobbili (Author/Creator)
M. Radivojkov‐Blagojevic (Author/Creator)
P. Lichtner (Author/Creator)
A.B. Singleton (Author/Creator)
D.G. Hernandez (Author/Creator)
C. Edsall (Author/Creator)
G.D. Mellick (Author/Creator)
A. Zimprich (Author/Creator)
W. Pirker (Author/Creator)
E. Rogaeva (Author/Creator)
A.E. Lang (Author/Creator)
S. Kõks (Author/Creator)
P. Taba (Author/Creator)
S. Lesage (Author/Creator)
A. Brice (Author/Creator)
J‐C Corvol (Author/Creator)
M‐C Chartier‐Harlin (Author/Creator)
E. Mutez (Author/Creator)
K. Brockmann (Author/Creator)
A.B. Deutschländer (Author/Creator)
G.M. Hadjigeorgiou (Author/Creator)
E. Dardiotis (Author/Creator)
L. Stefanis (Author/Creator)
A.M. Simitsi (Author/Creator)
E.M. Valente (Author/Creator)
S. Petrucci (Author/Creator)
S. Duga (Author/Creator)
L. Straniero (Author/Creator)
A. Zecchinelli (Author/Creator)
G. Pezzoli (Author/Creator)
L. Brighina (Author/Creator)
C. Ferrarese (Author/Creator)
G. Annesi (Author/Creator)
A. Quattrone (Author/Creator)
M. Gagliardi (Author/Creator)
H. Matsuo (Author/Creator)
Y. Kawamura (Author/Creator)
N. Hattori (Author/Creator)
K. Nishioka (Author/Creator)
S.J. Chung (Author/Creator)
Y.J. Kim (Author/Creator)
P. Kolber (Author/Creator)
B.P.C. Warrenburg (Author/Creator)
B.R. Bloem (Author/Creator)
J. Aasly (Author/Creator)
M. Toft (Author/Creator)
L. Pihlstrøm (Author/Creator)
L. Correia Guedes (Author/Creator)
J.J. Ferreira (Author/Creator)
S. Bardien (Author/Creator)
J. Carr (Author/Creator)
E. Tolosa (Author/Creator)
M. Ezquerra (Author/Creator)
P. Pastor (Author/Creator)
M. Diez‐Fairen (Author/Creator)
K. Wirdefeldt (Author/Creator)
N.L. Pedersen (Author/Creator)
C. Ran (Author/Creator)
A.C. Belin (Author/Creator)
A. Puschmann (Author/Creator)
C. Hellberg (Author/Creator)
C.E. Clarke (Author/Creator)
K.E. Morrison (Author/Creator)
M. Tan (Author/Creator)
D. Krainc (Author/Creator)
L.F. Burbulla (Author/Creator)
M.J. Farrer (Author/Creator)
R. Krüger (Author/Creator)
T. Gasser (Author/Creator)
M. Sharma (Author/Creator)
A. Elbaz (Author/Creator)
Publication Details: Movement Disorders, Vol.37(4), pp.857-864
Publisher: Wiley
Identifiers: 991005542794007891
Copyright: © 2022 International Parkinson and Movement Disorder Society
Murdoch Affiliation: Centre for Molecular Medicine and Innovative Therapeutics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.67 Parkinson's Disease
Web Of Science research areas: Clinical Neurology
ESI research areas: Neuroscience & Behavior