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Decreased physical working capacity in adolescents with Non-Alcoholic fatty liver disease reflects reduced iron bioavailability
Journal article   Peer reviewed

Decreased physical working capacity in adolescents with Non-Alcoholic fatty liver disease reflects reduced iron bioavailability

T. Mitchell, E. McKinnon, O.T. Ayonrinde, L.A. Adams, D. Trinder, A. Chua, R. Newton, L. Strakers and J.K. Olynyk
Hepatology, Vol.68, pp.1317A-1318A
2018
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Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is a common, chronic liver disorder related to obesity and insulin resistance. Iron metabolism is impaired in obese patients, often despite elevated serum ferritin levels. In healthy patients, iron deficiency has been associated with physical inactivity, however little is known regarding the relationship between iron metabolism and reduced physical capacity in individuals with NAFLD. We aimed to determine firstly, whether there was an association between iron bioavailability, as measured by mean cell volume (MCV) and transferrin saturation (TSAT), and physical work capacity, and secondly, whether NAFLD influenced this relationship…

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