Journal article
Decreased platelet APP isoform ratios in autosomal dominant Alzheimer's disease: Baseline data from a DIAN cohort subset
Current Alzheimer Research, Vol.12(2), pp.157-164
2015
Abstract
Introduction: This study examines platelet amyloid precursor protein (APP) isoform ratios of 120KDa to 110KDa (APPr) between mutation carriers (MC) carrying a mutation for autosomal dominant Alzheimer's disease (ADAD) and non-carriers (NC). Two previous studies reported no significant difference in APPr between ADAD MC and NC, which may have been due to the small sample size in both studies. The current study examines APPr in MC versus NC in a larger sample. In addition, it investigated whether APPr correlate with neuroimaging data, neuropsychological data and cerebrospinal fluid biomarkers in a cohort subset derived from the Dominantly Inherited Alzheimer Network (DIAN) study.
Methods: APPr were quantified by western blotting. Fifteen MC (symptomatic and asymptomatic) were compared against twelve NC using univariate general linear model. All participants underwent neuroimaging and neuropsychological testing which were correlated with APPr using Pearson's correlation coefficient (r).
Results: APPr were lower in MC compared to NC (p=0.003) while Mini-Mental State Examination (MMSE) scores were not significantly different (p>0.1). Furthermore, APPr inversely correlated with amyloid imaging in the Caudate Nucleus (r=-0.505; p<0.05) and Precuneus (r=-0.510; p<0.05).
Conclusion: APPr are lower in ADAD MC compared to NC, and inversely correlated with brain amyloid load prior to significant differences in cognitive health. However, the use of APPr as a biomarker needs to be explored further.
Details
- Title
- Decreased platelet APP isoform ratios in autosomal dominant Alzheimer's disease: Baseline data from a DIAN cohort subset
- Authors/Creators
- P. Chatterjee (Author/Creator) - School of Psychiatry and Clinical NeurosciencesV.B. Gupta (Author/Creator) - Edith Cowan UniversityA.M. Fagan (Author/Creator) - Washington University in St. LouisM.S. Jasielec (Author/Creator) - Washington University in St. LouisC. Xiong (Author/Creator) - Washington University in St. LouisH.R. Sohrabi (Author/Creator) - School of Psychiatry and Clinical NeurosciencesS. Dhaliwal (Author/Creator) - Curtin UniversityK. Taddei (Author/Creator) - Edith Cowan UniversityP. Bourgeat (Author/Creator) - Royal Brisbane and Women's HospitalB.M. Brown (Author/Creator) - School of Psychiatry and Clinical NeurosciencesT. Benzinger (Author/Creator)R.J. Bateman (Author/Creator) - Washington University in St. LouisJ.C. Morris (Author/Creator) - Washington University in St. LouisR.N. Martins (Author/Creator) - School of Psychiatry and Clinical Neurosciences
- Publication Details
- Current Alzheimer Research, Vol.12(2), pp.157-164
- Publisher
- Bentham Science Publishers
- Identifiers
- 991005545031307891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.57 Alzheimer's Mechanisms
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior