Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Clodagh Towns; Madeleine Richer; Simona Jasaityte; Eleanor J. Stafford; Julie Joubert; Tarek Antar; Alejandro Martinez-Carrasco; Mary B. Makarious; Bradford Casey; Dan Vitale; Kristin Levine; Hampton Leonard; Caroline B. Pantazis; Laurel A. Screven; Dena G. Hernandez; Claire E. Wegel; Justin Solle; Mike A. Nalls; Cornelis Blauwendraat; Andrew B. Singleton; Manuela M. X. Tan; Hirotaka Iwaki; Huw R. Morris; Sulev Koks; the Global Parkinson’s Genetics Program (GP2)

doi:10.1038/s41531-023-00533-w

Back

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Journal article

Open access

Peer reviewed

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Clodagh Towns, Madeleine Richer, Simona Jasaityte, Eleanor J. Stafford, Julie Joubert, Tarek Antar, Alejandro Martinez-Carrasco, Mary B. Makarious, Bradford Casey, Dan Vitale, …

NPJ Parkinson's Disease, Vol.9(1), 131

2023

DOI: https://doi.org/10.1038/s41531-023-00533-w

PMID: 37699923

Files and links (1)

pdf

Published1.32 MBDownload View

CC BY V4.0, Open Access

Abstract

Brief Communication

The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.

Details

Title: Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
Authors/Creators: Clodagh Towns - King's College London
Madeleine Richer - King's College London
Simona Jasaityte - King's College London
Eleanor J. Stafford - University College London
Julie Joubert - King's College London
Tarek Antar - National Institute on Aging
Alejandro Martinez-Carrasco - University College London
Mary B. Makarious - King's College London
Bradford Casey - Michael J. Fox Foundation
Dan Vitale - Data Tecnica International (United States)
Kristin Levine - Data Tecnica International (United States)
Hampton Leonard - Data Tecnica International (United States)
Caroline B. Pantazis - National Institute of Neurological Disorders and Stroke
Laurel A. Screven - National Institute of Neurological Disorders and Stroke
Dena G. Hernandez - National Institute on Aging
Claire E. Wegel - Indiana University – Purdue University Indianapolis
Justin Solle - Michael J. Fox Foundation
Mike A. Nalls - Data Tecnica International (United States)
Cornelis Blauwendraat - National Institute of Neurological Disorders and Stroke
Andrew B. Singleton - National Institute on Aging
Manuela M. X. Tan - Oslo, Norway
Hirotaka Iwaki - Data Tecnica International (United States)
Huw R. Morris - University College London
Sulev Koks - Murdoch University, Centre for Molecular Medicine and Innovative Therapeutics
the Global Parkinson’s Genetics Program (GP2)
Publication Details: NPJ Parkinson's Disease, Vol.9(1), 131
Publisher: Nature Publishing Group UK
Grant note: project ZO1 AG000949; project ZO1 AG000949; project ZO1 AG000949 /
Identifiers: 991005605570207891
Murdoch Affiliation: Murdoch University; Centre for Molecular Medicine and Innovative Therapeutics
Language: English
Resource Type: Journal article
Note: Sulev Koks appears courtesy of the Global Parkinson’s Genetics Program (GP2)

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Metrics

5 File views/ downloads

44 Record Views