Journal article
Definition of peptide binding motifs amongst the HLA-A*30 allelic group
Tissue Antigens, Vol.56(1), pp.10-18
2000
Abstract
HLA class I molecules present endogenously processed peptide ligands for surveillance by the T-cell receptor. This potentially immunogenic surface of HLA and peptide is a consequence of the polymorphism found within the HLA molecule and its preference for ligand binding together with peptide conformation within the binding groove. To investigate the relation between the polymorphic differences between some closely related HLA alleles and their effect on peptide preference, transfectants were established, each containing one of four allelic variants of HLA-A*30. Peptides from all four transfectants were eluted, and both individual ligands and peptide pools were sequenced. The data shows two distinct peptide motifs which distinguish A*3001 from the other three known A*30 variants. Differences in preferences at minor positions within the peptide sequence were noted between A*3002, A*3003 and A*3004, providing additional evidence of the implications of sequence polymorphism to HLA function.
Details
- Title
- Definition of peptide binding motifs amongst the HLA-A*30 allelic group
- Authors/Creators
- P. Krausa (Author/Creator) - MRC Human Immunology UnitC. Munz (Author/Creator) - University of TübingenW. Keilholz (Author/Creator) - University of TübingenS. Stevanovic (Author/Creator) - University of TübingenE.Y. Jones (Author/Creator) - Laboratory of Molecular Biophysics, Dept. of Biochemistry, Oxford, United KingdomM. Browning (Author/Creator) - University of LeicesterM. Bunce (Author/Creator) - Oxford Transplant Centre, Headington, Oxford. United KingdomH-G Rammensee (Author/Creator) - University of TübingenA. McMichael (Author/Creator) - MRC Human Immunology Unit
- Publication Details
- Tissue Antigens, Vol.56(1), pp.10-18
- Publisher
- Blackwell Publishing
- Identifiers
- 991005542311007891
- Copyright
- 2000 Munksgaard
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.607 MHC Diversity
- Web Of Science research areas
- Cell Biology
- Immunology
- Pathology
- ESI research areas
- Molecular Biology & Genetics