Journal article
Deletion of the Lsamp gene lowers sensitivity to stressful environmental manipulations in mice
Behavioural Brain Research, Vol.228(1), pp.74-81
2012
Abstract
The Lsamp gene gives rise to limbic system-associated membrane protein (LAMP), which is expressed on the surface of somata and proximal dendrites of neurons. Lsamp-deficient mice have been shown to be slightly hyperactive in novel environments and less anxious, and they display alterations in swimming speed, fear reaction, fear conditioning and social behaviour. In human studies, links between the LSAMP gene and several psychiatric disorders have been found and LSAMP has been established as a tumour suppressor gene. To study the impact of environmental manipulations on the phenotype, we exposed male Lsamp-deficient mice to environmental enrichment (EE), a technique that has often been shown to abolish phenotypic deviations in knockout mice, and to social isolation, a stressful manipulation, after which all the mice were tested in a behavioural battery. EE abolished differences between the genotypes in body weight and anogenital sniffing, a behaviour related to aggressiveness, and amplified the anxiolytic-like phenotype of Lsamp-deficient mice both in the plus maze and motility box. Isolation abolished differences between the genotypes in body weight and anxiety and amplified the differences in swimming speed and anogenital sniffing. EE and isolation failed to modify the results as compared to standard housing in whisker trimming, locomotor activity, marble burying and corticosterone levels. In conclusion, Lsamp-deficient mice were less sensitive to isolation stress than their wild-type littermates. Lack of LAMP protein seemingly leads to a deterioration in the ability to adapt to novel stressful environments and stimuli.
Details
- Title
- Deletion of the Lsamp gene lowers sensitivity to stressful environmental manipulations in mice
- Authors/Creators
- J. Innos (Author/Creator) - University of TartuM-A Philips (Author/Creator) - University of TartuS. Raud (Author/Creator) - University of TartuK. Lilleväli (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuE. Vasar (Author/Creator) - University of Tartu
- Publication Details
- Behavioural Brain Research, Vol.228(1), pp.74-81
- Publisher
- Elsevier B.V.
- Identifiers
- 991005544744407891
- Copyright
- © 2011 Elsevier B.V.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
15 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Citation topics
- 1 Clinical & Life Sciences
- 1.108 Molecular & Cell Biology - Cancer & Development
- 1.108.1986 NCAM
- Web Of Science research areas
- Behavioral Sciences
- Neurosciences
- ESI research areas
- Neuroscience & Behavior